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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/24164
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dc.contributor.authorIvanov, Mihaela
dc.contributor.authorCeban, Emil
dc.date.accessioned2023-05-04T06:45:03Z
dc.date.available2023-05-04T06:45:03Z
dc.date.issued2022
dc.identifier.citationIVANOV, Mihaela, CEBAN, Emil. Variability of urodynamic parameters in patients with idiopathic overactive bladder before intradetrusor botulinum toxin injections. In: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences. 2022, vol. 28(2), pp. 5-12. ISSN 2345-1467.https://doi.org/10.52645/MJHS.2022.2.01en_US
dc.identifier.issn2345-1467
dc.identifier.urihttps://cercetare.usmf.md/sites/default/files/inline-files/MJHS_28_2_2022.pdf
dc.identifier.urihttps://doi.org/10.52645/MJHS.2022.2.01
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/24164
dc.description.abstractAbstract Introduction. The aim of study was to establish if the treatment of overactive bladder in women and its result reported by patients were different depending on the findings of urodynamics, performed before botulinum toxin injection. We obtained clinical data based on the necessity and importance of performing urodynamic tests up to surgical treatment with botulinum toxin A injection in detrusor muscle, at patients diagnosed with idiopathic overactive bladder and detrusor overactivity, offering a guarantee of an effective and long-lasting treatment and assure with predictive parameters for some postoperative complications. Material and methods. The research was carried out at the Department of Urology and Surgical Nephrology, during the years 2019 – 2022. After applying the inclusion and exclusion criteria, 36 women diagnosed with overactive bladder were enrolled in the prospective pilot study, aged between 18 and 70 years, refractory to drug treatment and investigated urodynamic by excluding/including the presence of detrusor overactivity and clinically using voiding diary/24h, bladder symptoms and Quality of Life questionnaires before and after botulinum toxin A injection. The primary data were analyzed and presented as a mean and standard deviation. Results. All women involved in the study were diagnosed clinically and urodynamic with overactive bladder, of which 55.5% of cases were associated with detrusor overactivity and subsequently received BTX-A injectable surgical treatment with a dose of 100U. At urodynamics, the low values of the indices obtained at cystometry were established: first sensation of bladder filling (79.8 ± 56.3 ml), first desire to void (117.8 ± 103.2 ml), strong desire to void (162 ± 125 ml) and maximal cystometric capacity (183.4 ± 139.8 ml), which correlated in 100% cases with OAB symptoms (urinary urgency, frequency and nocturia) from the OABSS validated questionnaire. The capacity of the bladder at each sensation was lower, being inversely proportional to the detrusor overactivity present in women with OAB. Based on UDS data, the diagnosis of OABi with detrusor overactivity was confirmed by establishing the presence of phasic detrusor contractions (3.9 ± 1.1), increased values of detrusor pressure (45.9 ± 23.9 cmH2O) and the presence of bladder hypocompliance (10.6 ± 11.5 ml/cmH2O), these data in 100% of cases predicted an effective BTX-A injection. Daily activity and psychosocial behavior improved after intradetrusor botulinum injections toxin was influenced by reducing daytime urination from 28% to 40% and urinary urgency from 30 to 69%. Conclusions. This study identified a number of statistically significant urodynamic variables associated with objective clinical data, which confirm the impact of severity of idiopathic overactive bladder symptoms and the subsequent effect of botulinum toxin type A injections in case of urodynamic confirmation of detrusor overactivity presence.en_US
dc.language.isoenen_US
dc.publisherInstituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldovaen_US
dc.relation.ispartofRevista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciencesen_US
dc.subjectidiopathic overactive bladderen_US
dc.subjectdetrusor overactivityen_US
dc.subjectbotulinum toxinen_US
dc.subjectintravesical injectionsen_US
dc.subjectlower urinary tracten_US
dc.subject.ddcUDC: 616.62-008.222-089.819:615.217.5en_US
dc.titleVariability of urodynamic parameters in patients with idiopathic overactive bladder before intradetrusor botulinum toxin injectionsen_US
dc.typeArticleen_US
Appears in Collections:Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2022 nr. 2(28)



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