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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/24204
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dc.contributor.authorGroza, Costina-
dc.contributor.authorGroppa, Liliana-
dc.contributor.authorPopa, Serghei-
dc.contributor.authorSasu, Dorian-
dc.contributor.authorRotaru, Larisa-
dc.date.accessioned2023-05-05T09:39:26Z-
dc.date.available2023-05-05T09:39:26Z-
dc.date.issued2022-
dc.identifier.citationGROZA, Costina, GROPPA, Liliana, POPA, Serghei, et al. Impact of vitamin D in chronic kidney disease and its effect on the musculoskeletal system. In: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences. 2022, vol. 29(3), pp. 50-53. ISSN 2345-1467.en_US
dc.identifier.issn2345-1467-
dc.identifier.urihttps://cercetare.usmf.md/sites/default/files/inline-files/29_3_2022.pdf-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/24204-
dc.description.abstractAbstract. Introduction. Vitamin D plays an important role in maintaining musculoskeletal health. As the glomerular filtration rate decreases, vitamin D deficiency also occurs. The aim of this paper is to highlight the level of vitamin D depending on the stage of chronic kidney disease. Materials and methods. A structured search was performed in the PubMed, Scopus and HINARI databases, where the relevant articles have been taken into account, published in the last 20 years. The search terms used (in English) were: „vitamin D deficiency”, „pathogenesis of vitamin D”, ”the impact of vitamin D in chronic kidney disease”, „chronic kidney disease”. Results. Several studies have shown that the change in vitamin D levels is dependent to the decrease of glomerular filtration rate. The lowest serum vitamin D concentration was observed in stage 5 of chronic kidney disease. Vitamin D deficiency occurs due to a decrease in the number of nephrons and a decrease in the number of proximal tubular cells that absorb vitamin D (25 (OH) D) to be subsequently hydroxylated to its active form by 1α-hydroxylase. Conclusions. Patients with vitamin D-deficient due to chronic kidney disease have an increased risk of decreased bone mineral density and multiple fractures.en_US
dc.language.isoenen_US
dc.publisherInstituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldovaen_US
dc.relation.ispartofRevista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciencesen_US
dc.subjectvitamin Den_US
dc.subjectdeficiencyen_US
dc.subjectpathogenesisen_US
dc.subjectchronic kidney diseaseen_US
dc.subject.ddcUDC: 616.61-036.12+616.391:577.161.21/.22en_US
dc.titleImpact of vitamin D in chronic kidney disease and its effect on the musculoskeletal systemen_US
dc.typeArticleen_US
Appears in Collections:Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2022 nr. 3(29)

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