Etiologia exudatului bronșic la copiii cu maladii cronice bronhopulmonare complicate cu Aspergilus fumigatus

Abstract

Aim: Evaluation of the etiology of the bronchial exudate by bacteriological examination in children with chronic bronchopulmonary diseases complicated by Aspergillus fumigatus infection. Material and methods: In the retrospective clinical study, Aspergillus fumigatus co-infections with bacterial infections were evaluated in 53 children with chronic bronchopulmonary diseases. The bacteriological analysis was performed by examining the bronchial exudate. The infection with Aspergillus fumigatus was evaluated serologically (indirect hemaglutination), immunoenzymatic antigen. Statistically analyzed materials: Microsoft Excel, Epi Info –3.5. Results: The children in the study were distributed according to the nosological entity, such as with cystic fibrosis (CF) – 27 children (50,9%) and chronic bronchopulmonary diseases – 26 children (49,1%). In the children from the bacteriological study, infections were indentified with: unspecified gram negative germs (BNGN) were identified - 2 children (2,3%); Klebsiella pneumoniae – 5 children (5,8%); Ps.aeruginosa- 16 children (18,6%); Neisseria spp - 2 children (2,3%); Staphylococcus aureus – 20 children (23,3%); Streptococcus mitis/oralis – 1 child (1,2%); Streptococcus viridans – 9 children (10,5%), Titer of infection with Aspergillus fumigatus in the serum (IgM, IgA, IgG) of 21 children from the study equal to 1/803,8±17,3. Conclusions: Children with chronic bronchopulmonary diseases, Aspergillus fumigatus infection colonizes more frequently with Ps.aeruginosa (18,6%); Staphylococcus aureus (23,3%); Streptococcus viridans (10,5%).