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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/26701
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dc.contributor.authorDavid, Valeriu-
dc.contributor.authorFulga, Veaceslav-
dc.contributor.authorPetrovici, Vergil-
dc.contributor.authorCarpenco, Ecaterina-
dc.contributor.authorSaptefrati, Lilian-
dc.date.accessioned2024-01-10T12:20:25Z-
dc.date.available2024-01-10T12:20:25Z-
dc.date.issued2023-
dc.identifier.citationDAVID, Valeriu, FULGA, Veaceslav , PETROVICI, Vergil, CARPENCO, Ecaterina, SAPTEFRATI, Lilian. Ang1 immunoexpression vs vascular profile in chorio-villous germinative status in early term compromised pregnancies. In: The Moldovan Medical Journal. 2023, vol. 66, no 2, pp. 49-55. ISSN: 2537-6381, ISSN:2537-6373. https://doi.org/10.52418/moldovan-med-j.66-2.23.08en_US
dc.identifier.issn2537-6373-
dc.identifier.issn2537-6381-
dc.identifier.urihttps://doi.org/10.52418/moldovan-med-j.66-2.23.08-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/26701-
dc.description.abstractBackground: A normal maternal-fetal system is essential for the functioning of the placenta during placentation and the establishment of the maternalembryo-fetal vascular circulation. The angiopoietin/TIE pathway is involved in vascular morphogenesis through regulation, survival and maturation of endothelial cells concomitant with vascular remodeling. Deregulation of pro-angiogenic factor secretion and expression is associated with disruption of vascular morphogenesis, reduction of vascular bed and installation of primary placental insufficiency. The aim: Evaluation of Ang 1 immunoexpression in early term compromised pregnancies in the context of chorio-villary circulatory dysfunction in primary placental insufficiency. Material and methods: Abortion product from 61 patients (stagnant pregnancies – 39 cases, early miscarriage – 8 cases, control group – 14 cases of pregnancies solved on social indications/ desire) were immunohistochemically evaluated with the marker for anti-Ang1 and anti-CD31. Results: The villous syncytiotrophoblast was the most immunoreactive area. Most of cases of the pregnancies terminated on social indications/ desire were anti-Ang1 negative. The levels of anti-Ang1 immunoexpression were statistically significantly different in case of syncytiotrophoblast of early miscarriages and abortions terminated on social indications/ desire. The highest chorio-villous vascular density was noticed in the abortions on social indications/ desire and early misscariages group. Conclusions: The placental period is characterized by a weak angiogenic Ang1 differentiated cellular environment in the chorio-villous germinal site in the group of short term compromised pregnancies. The selectively immunoexpressed cellular profile statistically significantly correlates with placental vascular index and chorio-villous vascular density in stagnant pregnancies.en_US
dc.language.isoenen_US
dc.publisherThe Scientific Medical Association of the Republic of Moldovaen_US
dc.relation.ispartofThe Moldovan Medical Journalen_US
dc.subjectAng1en_US
dc.subjectangiogenesisen_US
dc.subjectfetal conceptusen_US
dc.subjectcompromised pregnanciesen_US
dc.subjectprimary placental dysfunctionen_US
dc.subject.ddcUDC: 618.36-008.64:618.344en_US
dc.titleAng1 immunoexpression vs vascular profile in chorio-villous germinative status in early term compromised pregnanciesen_US
dc.typeArticleen_US
Appears in Collections:Moldovan Medical Journal, December 2023, Vol. 66, No 2

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