USMF logo

Institutional Repository in Medical Sciences
of Nicolae Testemitanu State University of Medicine and Pharmacy
of the Republic of Moldova
(IRMS – Nicolae Testemitanu SUMPh)

Biblioteca Stiintifica Medicala
DSpace

University homepage  |  Library homepage

 
 
Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/26891
Full metadata record
DC FieldValueLanguage
dc.contributor.authorOjog, Victor-
dc.date.accessioned2024-03-11T10:38:26Z-
dc.date.available2024-03-11T10:38:26Z-
dc.date.issued2023-
dc.identifier.citationOJOG, Victor. Morphofunctional traits and reactivity of the portal vein. In: The Moldovan Medical Journal. 2023, nr. 2(66), pp. 83-90. ISSN 2537-6373. DOI: https://doi.org/10.52418/moldovan-med-j.66-2.23.13en_US
dc.identifier.issn2537-6373-
dc.identifier.issn2537-6381-
dc.identifier.urihttps://moldmedjournal.md/wp-content/uploads/2024/01/Moldovan-Med-J-2023-Vol66-No2_2.pdf-
dc.identifier.urihttps://doi.org/10.52418/moldovan-med-j.66-2.23.13-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/26891-
dc.description.abstractBackground: Portal vein is the most enigmatic vessel of our body because it regulates own contractile performances using a special pace-maker mechanism represented by cells of Cajal. The contribution of various metabolic mediators and natural vasotropic agents in the control of the portal blood circuit is much less studied compared to the arterial system in general and the hepatic system in particular. The studies designed on the structure, function, and reactivity of the portal vein in different preconditioning have brought some common but also distinct evidence of the arterial system. Nitric oxide production is higher partly due to reduced arginase expression, but muscular media is thinner. Periodic spontaneous contractions directed towards the liver gate are characteristic for portal vein (PV), and the longitudinal muscle fibers are considered to be responsible for this phenomenon. Spontaneous rhythmic oscillations of the cells of Cajal are triggered by increasing calcium ion concentration leading to their depolarization. PV constrictor effect of phenylephrine is dependent on the activity of receptors to ET-1. For PV is characterized the acetylcholine induced contraction either in vivo or in vitro, and this effect is thought to be dependent on ET-1. Conclusions: The establishment of main particularities of portal vein reactivity of action of different paracrine, endocrine, and hemodynamical stimuli represents an important tool for prediction of contractile disorders leading plausible to portal hypertension. Likewise, a well proven interplay between cholinergic and adrenergic stimulations and on the other hand between Ang II and ET-1 actions must be a support for pharmacological modulating of portal vein reactivity disorders.en_US
dc.language.isoenen_US
dc.publisherThe Scientific Medical Association of the Republic of Moldovaen_US
dc.relation.ispartofThe Moldovan Medical Journalen_US
dc.subjectportal veinen_US
dc.subjectmorphofunctional traitsen_US
dc.subjectvein reactivityen_US
dc.subject.ddcUDC: 611.149:616.149-008.341.1en_US
dc.titleMorphofunctional traits and reactivity of the portal veinen_US
dc.typeArticleen_US
Appears in Collections:Moldovan Medical Journal, December 2023, Vol. 66, No 2

Files in This Item:
File Description SizeFormat 
Morphofunctional_traits_and_reactivity_of_the_portal_vein.pdf266.29 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2013  Duraspace - Feedback