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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/27032
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dc.contributor.authorCeban, Marina-
dc.contributor.authorAnghelici, Gheorghe-
dc.contributor.authorZugrav, Tatiana-
dc.contributor.authorPisarenco, Sergiu-
dc.contributor.authorVasiliev, Radu-
dc.date.accessioned2024-04-22T07:10:28Z-
dc.date.available2024-04-22T07:10:28Z-
dc.date.issued2024-
dc.identifier.citationCEBAN, Marina, ANGHELICI, Gheorghe, ZUGRAV, Tatiana, et al. The results of the treatment of trophic ulcers of the lower limbs by applying autologous platelet-rich fibrin. In: Cells and Tissues Transplantation. Actualities and Perspectives: the materials of the nat. scientific conf. with internat. particip., the 2nd ed. Chisinau, March 29-30th 2024: [abstracts]. Chişinău: CEP Medicina, 2024, p. 23. ISBN 978-9975-82-366-1.en_US
dc.identifier.isbn978-9975-82-366-1-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/27032-
dc.description.abstractBackground. The most common cause of lower limb ulcers is chronic venous insufficiency.Up to 48% of patients with trophic ulcers are at the age of maximum productivity. 67% of patients with trophic ulcers become disabled, and in 81% the quality of life decreases considerably. Injection of autologous platelet-rich plasma (PRP) is an important factor in tissue regeneration and represents a new perspective in the treatment of trophic ulcers. Material and methods. Prospective study. The study included 28 patients, divided into 2 groups, with trophic ulcers of the lower limbs with a duration of 6-24 months without epithelization dynamics, paraclinically confirmed the presence of chronic venous insufficiency. I group 14 patients combined treatment with PRF injection in venous ulcers. II control group – 14 patients who benefited from general basic treatment and local compressive treatment. All patients were monitored for 1 year. On the 7th and 14th day of treatment, histological examinations of trophic ulcers were performed in both groups of patients, with a comparative evaluation of the results obtained. Platelet-rich fibrin membranes were obtained by centrifuging under special conditions the peripheral venous blood collected from the patient. Results. In group I complete epithelialization after 12 months of treatment combined with platelet-rich fibrin was obtained in 10 patients and in 4 patients incomplete epithelialization was obtained (70% of the ulcerated surface) In group II control after 12 months of treatment epithelialization complete epithelialization was obtained in 7 patients and incomplete epithelialization in 7 patients (40% of the ulcerated surface) The results of the histological examination demonstrated in Lot I the appearance of the neovascular network with granulation tissue in all patients. In batch II, the lack of formation of the neovascular network. Conclusions. The use of autologous Platelet-Rich Fibrin is a simple and affordable method to use. PRF membranes initiate and accelerate granulation tissue formation and angiogenesis. As a result, complete epithelization of the ulcers occurs, improving the patients' quality of life.en_US
dc.language.isoenen_US
dc.publisherCEP Medicinaen_US
dc.relation.ispartofCells and tissues transplantation. Actualities and perspectives. The 2-nd edition. Chisinau, March 29-30th 2024en_US
dc.subjectplatelet-rich fibrinen_US
dc.subjecttrophic ulceren_US
dc.subjectplateletsen_US
dc.subjectregenerationen_US
dc.subjectPRFen_US
dc.titleThe results of the treatment of trophic ulcers of the lower limbs by applying autologous platelet-rich fibrinen_US
dc.typeOtheren_US
Appears in Collections:The Materials of the National Scientific Conference with International Participation, the 2nd edition, Chisinau, March 29-30th 2024: [Abstracts]

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