USMF logo

Institutional Repository in Medical Sciences
of Nicolae Testemitanu State University of Medicine and Pharmacy
of the Republic of Moldova
(IRMS – Nicolae Testemitanu SUMPh)

Biblioteca Stiintifica Medicala
DSpace

University homepage  |  Library homepage

 
 
Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/27091
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCîvîrjic, Ivan-
dc.contributor.authorNerpii, Alina-
dc.contributor.authorStefanțov, Natalia-
dc.contributor.authorVoleac, Ina-
dc.contributor.authorCernei, Natalia-
dc.contributor.authorGherasim, Olga-
dc.contributor.authorȘandru, Serghei-
dc.date.accessioned2024-05-22T11:22:42Z-
dc.date.available2024-05-22T11:22:42Z-
dc.date.issued2024-
dc.identifier.citationCÎVÎRJIC, Ivan, NERPII, Alina, STEFANȚOV, Natalia, et al. Parameters predicting non-invasive ventilation failure in COVID-19 patients. In: Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences. 2024, nr. 1(11), pp. 3-10. ISSN 2345-1467. https://doi.org/10.52645/MJHS.2024.1.01en_US
dc.identifier.issn2345-1467-
dc.identifier.urihttps://doi.org/10.52645/MJHS.2024.1.01-
dc.identifier.urihttps://cercetare.usmf.md/sites/default/files/inline-files/Ivan%20C%C3%AEv%C3%AErjic%2C%20Alina%20Nerpii%2C%20Natalia%20Stefantov%2C%20Ina%20Voleac%2C%20Natalia%20Cernei%2C%20Olga%20Gherasim%2C%20Serghei%20%C8%98andru%20Parameters%20predicting%20non-invasive%20ventilation%20failure%20in%20COVID-19%20patients.pdf-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/27091-
dc.description.abstractIntroduction. During COVID-19 pandemic, non-invasive ventilation (NIV) was widely used during COVID-19 Pandemic. The factors predicting NIV failure in COVID-19 patients remain debatable. The goal of this research is to identify the parameters that may correlate NIV failure. Materials and methods. A retrospective analysis of COVID-19 patients’ data, who were admitted to ICU of the Institute of Emergency Medicine, Chisinau, during July-October 2020 and connected to NIV. The study analyzed the demographics, laboratory and respiratory parameters (at admission, at NIV initiation, 24-48h and 72-96h of NIV) and their relation with NIV failure. . For continuous variables, the established confidence interval was 95%. The Kruskal-Wallis H test was used for continuous variables and the Fisher’s exact test or chi-squared test was used for category data. Results. In study were included 154 patients. NIV failed in 52 patients. In NIV failure group were registered a higher rate of hypertension (88% vs 74%, p = 0.033), delirium (60% vs 20%, p=0.001) and need for sedation (83% vs 48, p=0.001). The urea levels were lower in NIV success group at admission, at NIV initiation and at 24-48h of NIV. The neutrophil/ lymphocyte ratio was higher in NIV failure group at NIV initiation; at 24-48h and 72-96h of NIV. NIV failure group had a higher level of WBC count and C-reactive protein at 24-48h and 72-96h as well as D-dimer at 72-96h of NIV. The ROX index was higher in NIV success group from NIV initiation and through 72h of NIV. Conclusions. The presence of abnormal values of neutrophil/lymphocyte ratio, urea, lymphocytes, WBC count, C-reactive protein, D-dimer and ROX index during non-invasive ventilation, as well as association of delirium and need for sedation, can be suggestive and informative for high risk of NIV failure in COVID-19 patients. Continuous measurement of these parameters may help the clinicians to decide the optimal timing of conversion to invasive ventilation.en_US
dc.language.isoenen_US
dc.publisherInstituţia Publică Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” din Republica Moldovaen_US
dc.relation.ispartofRevista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciencesen_US
dc.subjectnon-invasive ventilationen_US
dc.subjectCOVID-19en_US
dc.subjectROX indexen_US
dc.subjectfailure predictorsen_US
dc.subjecthypoxemic respiratory failureen_US
dc.subject.ddcUDC: 616.24-085.816-037:616.98:578.834.1en_US
dc.titleParameters predicting non-invasive ventilation failure in COVID-19 patientsen_US
dc.typeArticleen_US
Appears in Collections:Revista de Științe ale Sănătății din Moldova : Moldovan Journal of Health Sciences 2024 nr. 1(11)

Files in This Item:
File Description SizeFormat 
Parameters_predicting_non_invasive_ventilation_failure.pdf769.53 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2013  Duraspace - Feedback