Clinical - epidemiological impact of vaccination in rotaviral infection in infants: Summary of Doctoral Thesis in Medical Sciences: 322.01 – Pediatrics and neonatology

Abstract

[...] THE RESEARCH CONCEPTUAL FRAMEWORK Actuality and significance of the research topic Rotaviruses (RV) are the most common causes of acute gastroenteritis (AGE) worldwide, affecting 95.0% of children under the age of five. Globally, RV infection is estimated to cause 3.6 million episodes of AGE per year [1, 2]. Prior to the worldwide rotavirus vaccine implementation, more than 2 million children with rotavirus-related AGE were hospitalized annually [2, 3]. By the age of five, almost every child has suffered from rotavirus infection (RVI), which is the leading cause of severe diarrhea and dehydration in infants worldwide. In low-income countries, the mean age of primary RV infection occurs in infants aged 6- 9 months (in 80.0% of infants under 1 year), whereas in high-income countries the first episode commonly occurs at the age of 2-5 years, the most affected being the infants ( in 65.0% of cases) [3, 4]. [...]