The influence of vitamin D on the clinical course of the disease in patients with pulmonary tuberculosis

Abstract

Introduction. Vitamin D insufficiency or deficiency is defined as a very common condition in the general population. Vitamin D deficiency has a positive effect on a wide range of microbial infections, such as gram-positive and gram-negative bacteria, fungi, mycobacteria, and viruses. The aim of the study. To determine the level of vitamin D in patients with susceptible pulmonary tuberculosis. Materials and methods. The randomized case-control study included 45 patients with newly diagnosed pulmonary tuberculosis (PDTB] of the lungs with preserved sensitivity and 30 practically healthy individuals (PHI) of the control group. The level of vitamin D in blood serum was examined using the VD (Vitamin D) ELISA Kit (Optics Valley Biomedical Industrial Park, Wuhan, China (430075)). Results. It was established that the average level of 2 5 (OH) D concentration in the blood serum of patients with pulmonary tuberculosis was 18.46±4.23 ng/ml, in the control group it was 28.834±5.79 ng/ml and was statistically significant (p = 0.001). Our multivariate studies showed a strong direct relationship between the presence of a specific tubercular process and vitamin D deficiency (<20 ng/ml) (OR 2.817, 95%, Cl 1.287 - 4.894, P < 0.005). Conclusions. Vitamin D deficiency was noted in 94% of patients with pulmonary tuberculosis with severe intoxication syndrome (7-10 points). In tuberculosis with moderate intoxication syndrome (4-6 points), 69.7% of patients had a vitamin D deficiency, which practically did not differ from indicators in patients with mild intoxication syndrome (1-3 points) - 67.2% of people.