| DC Field | Value | Language |
|---|
| dc.contributor.author | Dolma, Nadejda | |
| dc.contributor.author | Beţiu, Mircea | |
| dc.date.accessioned | 2019-06-24T22:41:25Z | |
| dc.date.available | 2019-06-24T22:41:25Z | |
| dc.date.issued | 2016 | |
| dc.identifier.citation | DOLMA, Nadejda, BEŢIU, Mircea. Rolul barierei cutanate şi mutaţiile genei filagrinei in patogenia dermatitei atopice. In: Curierul Medical. 2016, vol. 59, no 3, pp. 18-22. ISSN 1875-0666. | |
| dc.identifier.issn | 1857-0666 | |
| dc.identifier.uri | http://repository.usmf.md/handle/20.500.12710/2966 | |
| dc.identifier.uri | http://moldmedjournal.md/wp-content/uploads/2016/09/Cm-3-PDF-1.pdf | |
| dc.description | Institutul Mamei şi Copilului, Catedra Dermatovenerologie, Universitatea de Stat de Medicină şi Farmacie “Nicolae Testemiţanu”, Chişinău, Republica Moldova, Congresul V Naţional de Dermatologie cu participare internaţională Chişinău, 9-11 iunie 2016, Chişinău, Republica Moldova | en_US |
| dc.description.abstract | Atopic dermatitis (AD) is a multifactorial, heterogenous disease that arises as a result of the interaction between both environmental and genetic
factors. Loss-of-function mutations found within the FLG gene encoding the structural protein, filaggrin, represent the most significant genetic factor
predisposing to AD identified to date. In this article is reviewed the updated one of the genetic factors predisposing to AD, namely, a failure of skin barrier
function undermined by mutations in the fillagrin gene. These genetic defects are responsible for enhanced permeability of the skin for allergens while
epicutaneous sensitization promotes the development of atopic dermatitis. | en_US |
| dc.language.iso | ro | en_US |
| dc.publisher | Ministerul Sănătăţii al Republicii Moldova, Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” | en_US |
| dc.relation.ispartof | Curierul Medical: Congresul V Naţional de Dermatologie cu participare internaţională Chişinău, 9-11 iunie 2016, Chişinău, Republica Moldova | |
| dc.subject | atopic dermatitis | en_US |
| dc.subject | genetic mutations | en_US |
| dc.subject | fillagrin | en_US |
| dc.subject | skin barrier | en_US |
| dc.subject.mesh | Dermatitis, Atopic | en_US |
| dc.subject.mesh | Skin | en_US |
| dc.title | Rolul barierei cutanate şi mutaţiile genei filagrinei în patogenia dermatitei atopice | en_US |
| dc.title.alternative | Epidermal barrier and mutations in the fillagrin gene in pathogenesis of atopic dermatitis | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | Curierul Medical, 2016, Vol. 59, No 3
|
