| DC Field | Value | Language |
|---|
| dc.contributor.author | Groppa, Liliana | |
| dc.contributor.author | Hellis, Osama | |
| dc.contributor.author | Russu, Eugeniu | |
| dc.date.accessioned | 2019-06-26T11:24:05Z | - |
| dc.date.available | 2019-06-26T11:24:05Z | - |
| dc.date.issued | 2013 | |
| dc.identifier.citation | GROPPA, Liliana, HELLIS, Osama, RUSSU, Eugeniu. Răspunsul terapeutic al triplei terapii combinate cu metotrexat, leflunomid şi wobenzym în artrita reumatoidă. In: Anale Științifice ale IP USMF “Nicolae Testemiţanu”. Ed. a 14-a. Chișinău: CEP Medicina, 2013, Vol. 3: Probleme actuale în medicina internă, pp.214-222. | en_US |
| dc.identifier.uri | http://repository.usmf.md/handle/20.500.12710/5962 | - |
| dc.description | Clinica Medicală nr.5, disciplina Reumatologie şi Nefrologie
USMF ”Nicolae Testemiţanu” | en_US |
| dc.description.abstract | Significant improvement on the ACR criteria (> 50) at the end of the study was observed
in most patients treated with methotrexate, leflunomide and Wobenzym. This is confirmed by a
statistically and clinically significant with the positive dynamics of indicators (pain, stiffness,
painful and swollen joints, RA activity, ESR, HAQ). The use of triple therapy decreased the
average dose of simultaneous use of corticosteroids (from 5,0 to 2,5 mg) and 76% of patients
have canceled NSAIDs. This result was observed in a population of patients selected on the basis
of "intent-to-treat", i.e. during the primary effectiveness analysis.
O îmbunătăţire considerabilă a criteriilor ACR (>50) a fost observată la majoritatea
pacienţilor trataţi cu MTX, leflunomidă şi Wobenzym. Acest fapt este confirmat de dinamică
pozitivă statistică şi clinică a indicilor (durerea, redoarea, articulaţiile dureroase şi tumefiate,
activitatea AR, VSH, HAQ). Utilizarea triplei terapii a scăzut doza medie utilizată de
corticosteroizi (de la 5,0 la 2,5 mg), iar 75% au anulat tratamentul cu AINS. Acest rezultat a fost
215
observat la pacienţii selectaţi pe baza ”intent-to-treat”, adică în urma analizei primare a
eficacităţii. | en_US |
| dc.language.iso | ro | en_US |
| dc.publisher | CEP "Medicina" | en_US |
| dc.subject | leflunomid | en_US |
| dc.subject | methotrexat | en_US |
| dc.subject | wobenzym | en_US |
| dc.subject.mesh | arthritis, rheumatoid - drug therapy | en_US |
| dc.subject.mesh | drug therapy, combination | en_US |
| dc.title | Răspunsul terapeutic al triplei terapii combinate cu metotrexat, leflunomid şi wobenzym în artrita reumatoidă | en_US |
| dc.title.alternative | Efficacy of combined triple therapy methotrexate, leflunomide and wobenzym at patients with rheumatoid arthritis | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | Reumatologie
|
