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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/6917
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dc.contributor.authorUsenko, Tetiana
dc.contributor.authorShulyak, Valentyna
dc.date.accessioned2019-11-04T13:13:39Z
dc.date.available2019-11-04T13:13:39Z
dc.date.issued2016
dc.identifier.citationUSENKO, Tetiana, SHULYAK, Valentyna. Hematological study of generic pesticides quizalophop-P-ethyl. In: Sănătate Publică, Economie şi Management în Medicină. 2016, nr. 6(70), p. 142. ISSN 1729-8687.en_US
dc.identifier.issn1729-8687
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/6917
dc.identifier.urihttp://revistaspemm.md/wp-content/uploads/2019/05/cm6_70_2016_cg.pdf
dc.descriptionLaboratory of Pathology, L.I. Medved’s Scientific Center of Preventive Toxicology, Food and Chemical Safety Ministry of Health, Ukraine, Kiev, Prima Conferință științifico-practică națională cu participare internațională ”Siguranţa chimică și toxicologia la confluenţa dintre domenii” 24-25 noiembrie 2016 Chișinău, Republica Moldovaen_US
dc.description.abstractThe aim of the study was to research the exposure effects of generic pesticides quizalophopP-ethyl, 98,2% (QpE 1), quizalophop-P-ethyl, 95% (QpE 2) and quizalophop-P-ethyl, 95,9% (QpE 3) on hematological parameters of males Wistar Han rats in the sub chronic 90-days oral toxicity study (according to OECD 408 guideline in compliance with GLP). Doses (0; 2; 10; 100 mg/kg) were defined. Blood for hematological measurements was studied at 4, 9, 13 weeks after QpE exposure in the same groups of animals throughout the experiment. Hematological parameters: RBC, HGB, HCT, erythrocyte indices (MCV, MCH, MCHC), total amount of leukocytes (WBC) and platelets were measured. As a result: QpE 1 in 100 mg/kg dose induced significant decrease of MCH and MCHC after 9 weeks of exposure and significant decrease of RBC and HGB concentration after 13 weeks of exposure. QpE 2 in 100 mg/kg dose after 4 weeks of exposure caused significantly increased of total WBC value. MCHC was significantly decreased at the highest dose of QpE 2 in all experimental periods compared to the control group. QpE 3 in 100 mg/kg dose demonstrated significantly increased of total WBC value and significant decrease of MCHC after 13 weeks of exposure. The study revealed that QpE 1, QpE 2, QpE 3 promote hematological alterations on the high dose level. In this case, the impurities of generic pesticides QpE can demonstrate toxicological action as adverse effects on blood system.
dc.language.isoenen_US
dc.publisherAsociația Obștească ”Economie, Management și Psihologie în Medicină” din Republica Moldovaen_US
dc.subjectblooden_US
dc.subjecthematological parametersen_US
dc.subjectgeneric pesticideen_US
dc.subjectquizalophop-P-ethylen_US
dc.subjectWistar Han ratsen_US
dc.subject.meshPesticides--adverse effectsen_US
dc.subject.meshPesticides--blooden_US
dc.subject.meshPesticides--toxicityen_US
dc.titleHematological study of generic pesticides quizalophop-P-ethylen_US
dc.typeOtheren_US
Appears in Collections:Sănătate Publică, Economie şi Management în Medicină Nr. 6 (70) / 2016

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