USMF logo

Institutional Repository in Medical Sciences
of Nicolae Testemitanu State University of Medicine and Pharmacy
of the Republic of Moldova
(IRMS – Nicolae Testemitanu SUMPh)

Biblioteca Stiintifica Medicala
DSpace

University homepage  |  Library homepage

 
 
Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/7444
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDanilov, L.
dc.contributor.authorAbabii, Ion
dc.contributor.authorGhinda, S.
dc.contributor.authorNacu, V.
dc.contributor.authorManiuc, M.
dc.contributor.authorSmetanca, V.
dc.date.accessioned2020-02-12T10:04:13Z
dc.date.available2020-02-12T10:04:13Z
dc.date.issued2014
dc.identifier.citationDANILOV, L., ABABII, I., GHINDA, S., NACU, V., MANIUC, M., SMETANCA, V. Importanţa imunostimulării locale în tratamentul conservator complex al amigdalitei cronice la copii. In: Curierul Medical. 2014, vol. 57, no 6, pp. 7-13. ISSN 1875-0666.en_US
dc.identifier.issn1875-0666
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/7444
dc.identifier.urihttp://moldmedjournal.md/wp-content/uploads/2016/09/Cm-6-2014-Electronic-version.pdf
dc.descriptionDepartment of Otorhinolaryngology, Nicolae Testemitsanu State University of Medicine and Pharmacy, Laboratory of Immunology and Allergology, Chiril Draganiuc Institute of Phtisiopulmonology, Laboratory of Tissue Engineering and Cells Cultures, Chisinau, the Republic of Moldovaen_US
dc.description.abstractBackground: Chronic respiratory infections affect the particularitation of general immune system, impaired local immunity and increased frequency of allergic diseases. The methods used in the treatment of chronic tonsillitis are not effective enough and now it is required developing new diagnostic criteria and reasonable tactics complex conservative therapy. Modern methods of treatment of chronic tonsillitis are oriented to normalization of general immune status of the body, restoring the function of drainage gaps tonsil, hypo-sensitization, and decreased symptoms of local inflammation. Material and methods: The children with compensated chronic tonsillitis were divided into two groups: 26 patients (1-st group) were subjected to therapeutic traditional treatment and immunomodulatory local treatment with application of activated mononuclear autocells and 26 patients (2-nd group), that have been treated by traditional therapeutic method. All patients were tested: the functional activity of neutrophils in nitro-blue tetrazolium test (NBT); the content of phagocytic neutrophils and their phagocytic activity; total hemolytic activity of the complement; normal antibody titer, lymphocyte subpopulations were determinated by immunofluorescence using monoclonal antibodies reaction; the level of immunoglobulins; the content of circulating immune complexes; ASL-O rheumatoid factor; reactive protein – C; blast transformation reaction of lymphocytes with phytohaemaglutinin. The smear was taken from the patients and the bacterial flora and its susceptibility to antibiotics before and after the conservative treatment was investigated. Results: After treatment, in 1-st group comparativly 2-nd group, was appreciated a more pronounced decrease in the levels of indexes CIC, IgE, CD-4/CD-8 antigens streptococcus sensitivity and a greater increase of phagocytic activity and the number of neutrophils, the functional activity of T-lymphocytes. Conclusions: Thanks to investigations of preimmune reactivity and immunological changes in the body in case of compensated chronic tonsillitis in children was appreciated the effectiveness of conservative treatment with topical application of complex activated mononuclear autolimfocite that has a positive effect with clinical and immunological high level.en_US
dc.language.isoroen_US
dc.publisherThe Scientific Medical Association of the Republic of Moldovaen_US
dc.relation.ispartofCurierul Medical
dc.subjectchronic tonsillitisen_US
dc.subjectimmunityen_US
dc.subjectpalatine tonsilsen_US
dc.subjectchildrenen_US
dc.subject.meshTonsillitis--etiologyen_US
dc.subject.meshTonsillitis--immunologyen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshPalatine Tonsilen_US
dc.subject.meshImmunotherapyen_US
dc.titleImportanţa imunostimulării locale în tratamentul conservator complex al amigdalitei cronice la copiien_US
dc.title.alternativeThe importance of local immunostimulation in complex treatment of chronic tonsillitis in childrenen_US
dc.typeArticleen_US
Appears in Collections:Curierul Medical, 2014, Vol. 57, Nr. 6



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2013  Duraspace - Feedback