Функциональное состояние фетоплацентарного комплекса у женщин с большим интергенетическим интервалом

Abstract

The examination of 70 pregnant women have been conducted, among them there have been 30 women with a long (over 10 years) intergenetic interval between giving the first and the second births (the first group), 20 aged primigravidas have been included in the second group and 20 pregnant women who have had a birth with a break of 3-5 years have been included in the third group (control group). The average age of the women of group I was 33.3 years old, of group II – 36.5 years old, of group III – 28.4 years old. All the studied hormones of the women with big intergenetic intervals have been significantly reduced with respect to the comparison group (III). In the women of the Ist group they decreased by 2.8 times, and in the women of the IInd they group – by 2.4 times with respect to the comparison group. The concentration of cortisol in the blood serum of the women of the Ist and IInd groups has significantly increased. The indicator of the first group has been significantly higher than that of the second group. Large birth spacing in pregnant women is accompanied by a significant decrease in the concentration of the hormones of placenta, which characterizes the state of placental insufficiency in the majority of the women at the 26-28th week of gestation period. The increase of serotonin concentration and the decrease of progesterone concentration can be attributed to the women with a long intergenetic interval, who are at risk of the development of a preterm birth. A significant increase of cortisol and serotonin in the blood of the women with a long intergenetic interval indicates a disorder of the adaptation mechanisms in this group of pregnant women. One-pointedness of the hormonal changes in the women with a long intergenetic interval and the age factor of the primiparous women confirm the role of age in the development of hormonal disorders in the pregnant women of the examined contingent.