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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/7856
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dc.contributor.authorSavrun, T. I.
dc.date.accessioned2020-03-23T20:24:05Z
dc.date.available2020-03-23T20:24:05Z
dc.date.issued2013
dc.identifier.citationSAVRUN, T. I. Проблема диагностики гипоксической нефропатии у недоношенных новорожденных и пути ее решения. In: Curierul Medical. 2013, vol. 56, no 6, pp. 63-67. ISSN 1875-0666.ru
dc.identifier.issn1875-0666
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/7856
dc.identifier.urihttp://moldmedjournal.md/wp-content/uploads/2016/09/75.pdf
dc.description.abstractThe study included 120 premature infants suffering from perinatal hypoxia, which have been divided into two groups by birth weight: group 1 – less than 1500 g, group 2 – more than 1500 g. Severity of renal disease was defined by creatinine and cystatin C levels in serum, interleukin-18 (IL-18) and lipocalin (NGAL) levels in urine on the 3rd-5th day of life, parameters of renal blood flow. The study found a significant increase (3 times) of serum creatinine in children of the test groups (p < 0.05) compared to the controls. The serum levels of cystatin C on the 3rd-5th day of life were 2.6 ± 0.21 ng/ ml (group 1) and 1.9 ± 0.12 ng/ml (group 2) that is significantly higher than in the controls (p < 0.01). The content of NGAL in newborns suffering from hypoxic nephropathy was 2.5-3 times higher than in the controls (p < 0.01). IL-18 levels were significantly higher too (p < 0.01). Renal blood flow investigation showed a significant decrease of systolic flow velocity in the trunk of the renal arteries and of pulsatility index (PI) among newborns affected. The study established clinical and laboratory features of hypoxic nephropathy in premature infants – edema and proteinuria of various severity, early significant increase in serum cystatin C, as well as lipocalin and IL-18 in urine, a significant reduction of the maximal systolic flow velocity in the trunk of the renal arteries and PI (p < 0.05) - that were more evident among the children with weight < 1500 g.en_US
dc.language.isoruen_US
dc.publisherMinisterul Sănătăţii al Republicii Moldova, Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”en_US
dc.subjectpremature newbornsen_US
dc.subjecthypoxic nephropathyen_US
dc.subjectcystatin Cen_US
dc.subjectlipocalinen_US
dc.subjectinterleukin-18en_US
dc.subject.meshKidney Diseases--diagnosisen_US
dc.subject.meshKidney Diseases--physiopathologyen_US
dc.subject.meshChilden_US
dc.subject.meshFetal Hypoxiaen_US
dc.subject.meshInfant, Prematureen_US
dc.titleПроблема диагностики гипоксической нефропатии у недоношенных новорожденных и пути ее решенияru
dc.title.alternativeThe problem of hypoxic nephropathy diagnosis in premature infants and its solutionsen_US
dc.typeArticleen_US
Appears in Collections:Curierul Medical, 2013, Vol. 56, Nr. 6

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