Reparative osteogenesis in normal conditions and micronutrient iodine deficiency

Abstract

Background: Today without attention of researchers a number of issues remain unsolved and require their study, including: the impact of iodine deficiency conditions on bone health, healing of bone defects and morphological characteristics of the process concerning iodine deficiency. Material and methods: The experiments were performed on 63 rendobrand albino male rats, 3-month old. The experiment was performed on the control, and the main groups of animals. The main group consisted of 42 rats, subdivided into two subgroups, with 21 experimental animals each. Iodine deficiency was modeled in the animals of the main group by using the diet with low iodine content (6 mg / 100 g) and using the drug daily during 21 days, once a day in the stomach in the form of aqueous starch suspension. Reparative osteogenesis was studied by means of histomorphological examination on the 7, 15 and 30th days after producing femoral defect with the diameter of 1 mm. Results: The data obtained are indicative of negative effects of iodine deficiency on reparative osteogenesis and saline, demonstrating the suppression of these processes, involving disorders of forming callus, deterioration of the structural-functional state of the bone development, degenerative and necrotic changes in bone and epiphyseal cartilage. Conclusions: In animals of the experimental group with simulated iodine deficiency regenerative bone formation was delayed and developed against the ground of pronounced disorders of blood supply. The reparative process was characterized by inhibition of formation and remodeling of the regeneration, leading to decrease in a relative area of lamellar bone tissue as compared to the controls.