Dynamics of proinflammatory (TNF-α) and anti-inflammatory (IL-10) cytokines in different clinical forms and variants of children chickenpox

Abstract

Background: Research of the levels of tumor necrosis factor -α and interleukin-10 in serum of children with chickenpox in different clinical forms and variants of the disease. Material and methods: 84 children aged from 5 months to 14 years were tested to determine cytokine concentration. The dynamics of the content characteristics of necrosis factor tumor-α and interleukin-10 in serum of children with different clinical forms and variants of children chickenpox was studied. Statistical analysis was performed using the statistical software package “STATISTICA FOR WINDOWS 5,0” (StatSoft, USA, 1998). Results: It was determined that the dynamics of the content characteristics of studied cytokines varied depending on the clinical form and variant of the disease. For uncomplicated varicella only necrosis factor tumor-α increase is typical. Significant increase of both studied cytokines was found in groups of children with complicated chickenpox. The imbalance in the system of cytokines with bacterial complications of varicella reflects the high activity of the inflammatory process. Conclusions: These results confirm the feasibility of using indicators of TNF-α and IL-10 not only to assess the severity of chickenpox, but to predict the development of bacterial complications.