Antibiotics consumption evaluation in reanimation department

Abstract

Background: Unnecessary use of anti-infectives for systemic use is a major global issue and often results in too many problems such as: ineffective treatment and side effects in patients, increase of the risk of development of pathogen microbial resistance and treatment costs. Defined daily doses (DDD) is a method that integrated the evaluation of drugs consumption of worldwide hospitals, giving the possibility of comparison, improving the rational use, optimizing the possibility of coherent planning of antibiotics necessities. Material and methods: The data of this study represents a six-year (2009-2014) period in Reanimation Department, which describes the consumption dynamics of anti-infectives for systemic use of drugs in natural and value indexes. Results: The defined daily doses (DDD) per 1000 occupied-bed days (DDD/1000) of antibiotics in Reanimation Department has decreased from 3270.17 in 2009 to 1664.99 in 2014 and is by 22.76% higher than medium consumption of 1286.11 DDD/1000 in 1134 intensive care units from international hospitals. The value indexes per DDD/1000 declined from 87860 in 2009 to 54307 lei in 2014 or by 38.19%, when the cost of one medium DDD increased from 26.87 in 2009 to 32.62 lei or by 21.40% in 2014. The pharmacoeconomy from 2010 to 2014 increased more than by 3 times. Conclusions: The stated decrease in DDD/1000 OBD and the obtained pharmacoeconomy characterized the measures taken to improve the rational use of antibiotics. The increase of one DDD cost, shows the increase in the price of antibiotic medical remedies for the evaluated period.