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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/9841
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dc.contributor.authorFeghiu, Iuliana
dc.contributor.authorBaltaga, Ruslan
dc.contributor.authorFrunză, Galina
dc.contributor.authorTazlavan, Tatiana
dc.contributor.authorȘandru, Sergiu
dc.date.accessioned2020-05-26T07:46:04Z
dc.date.available2020-05-26T07:46:04Z
dc.date.issued2018
dc.identifier.citationFEGHIU, Iuliana, BALTAGA, Ruslan, FRUNZĂ, Galina, TAZLAVAN, Tatiana, ȘANDRU, Sergiu. Baseline heart parasympathicotonia – a risk factor for cardiovascular instability in anesthesia induction with propofol or midazolam. In: The Moldovan Medical Journal. 2018, vol. 61 (AIC congress issue), september, p. 34. ISSN 2537-6381.en_US
dc.identifier.issn2537-6381
dc.identifier.urihttp://moldmedjournal.md/wp-content/uploads/2018/09/61-4-ATI-Congres.pdf
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/9841
dc.descriptionDepartment of Anestesiology and Reanimatology No1, Nicolae Testemitsanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova, The 5th International Congress of the Society of Anesthesiology and Reanimatology of the Republic of Moldova, 16th Edition of the International Course of Guidelines and Protocols in Anesthesia, Intensive Care and Emergency Medicine, 28th Meeting of the European Society for Computing and Technology in Anesthesia and Intensive Care September 27-29, 2018, Chisinau, the Republic of Moldovaen_US
dc.description.abstractBackground: Aim of the study. Evaluation of relationship between baseline parasympathetic heart tonus and the frequency of adverse cardiovascular reactions in anesthesia induction with propofol or midasolam. Material and methods: The study was performed within Institute of Emergency Medicine and was approved by the Ethic Committee of the USMF ”N. Testemițanu”. In the study groups were involved 94 patients scheduled for elective general surgery with age 38,6±11,4 years and BMI 27,6±3,7 kg/m2. Heart rate variability was registered with Holter TLC 5000 device: 5 minutes in baseline, 5 minutes after intravenous administration of fentanyl 1,0 mkg/kg and 5 minutes after intravenous administration of 2,5 mg/kg propofol with 2,0 mkg/kg fentanyl or 0,2-0,3 mkg/kg midasolam with 2,0 mkg/kg fentanyl. Results: Baseline heart parasympathicotonia enhances the risk of sinus bradycardia (relative risk-7,7(95%CI 1,9-29,7), Odds Ratio–21,0 (95%CI 3,9-112,8) (p<0,0002), as well as the risk of sinus bradycardia associated with arterial hypotension (relative risk-6,2 (95%CI 2,1 -18,6), Odds Ratio-19,2(95%CI 4,1–88,6) (p<0,0001), after administration of propofol for induction of general anesthesia. Baseline heart parasympathicotonia enhances the risk of sinus bradycardia: (relative risk-4,5 (95%CI 1,7- 11,4), Odds Ratio–13,1(95%CI 3,1-54,7) (p=0,0002), the risk of arterial hypotension: (relative risk-4,8(95%CI 1,6-14,5), Odds Ratio-12,7(95%CI 2,9-55,9) (p=0,0003), as well as the risk of sinus bradycardia associated with arterial hypotension: (relative risk-3,5(95%CI 1,8-7,1), Odds Ratio-13,7(95%CI 3,0–62,7) (p=0,0003), after administration of midasolam for induction of general anesthesia. Conclusions: Baseline heart parasympathicotonia is a risk factor for development of sinus bradycardia and arterial hypotension after administration of midasolam or propofol for induction of general anesthesia.
dc.language.isoenen_US
dc.publisherThe Scientific Medical Association of the Republic of Moldovaen_US
dc.relation.ispartofThe Moldovan Medical Journal: The 5th International Congress of the Society of Anesthesiology and Reanimatology of the Republic of Moldova, 16th Edition of the International Course of Guidelines and Protocols in Anesthesia, Intensive Care and Emergency Medicine, 28th Meeting of the European Society for Computing and Technology in Anesthesia and Intensive Care September 27-29, 2018, Chisinau, the Republic of Moldova
dc.subjectheart parasympathicotoniaen_US
dc.subjectpropofolen_US
dc.subjectmidazolamen_US
dc.titleBaseline heart parasympathicotonia – a risk factor for cardiovascular instability in anesthesia induction with propofol or midazolamen_US
dc.typeArticleen_US
Appears in Collections:The Moldovan Medical Journal, Vol. 61, September 2018 AIC Congress Issue



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