http://repository.usmf.md:80/xmlui/handle/20.500.12710/11502 2026-04-12T23:02:42Z 2026-04-12T23:02:42Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/16910 2021-09-22T14:53:49Z 2020-01-01T00:00:00Z

The Moldovan Medical Journal. June 2020, Vol. 63, No 2 The Moldovan Medical Journal is an international scientific double-blind peer-reviewed periodical edition, 4 per year, of the Scientific Medical Association of the Republic of Moldova designed for specialists in the areas of medicine, dentistry, pharmacy, social medicine, and public health. From its debut, the journal has striven to support the interests of Moldovan medicine concerning the new concepts of its development. The Editorial Board warmly welcomes both the readers of and the authors of the journal, all those who are enthusiastic about searching for new and more effective ways of solving numerous medical problems. We hope that those who want to make their contribution to the science of medicine will find our journal helpful and encouraging. Founder: The Scientific Medical Association of the Republic of Moldova

2020-01-01T00:00:00Z Portnoi, Elena http://repository.usmf.md:80/xmlui/handle/20.500.12710/11702 2021-09-22T15:13:57Z 2020-01-01T00:00:00Z

Identification and clinical significance of folliculo-stellate cells in normal hypophysis and adenomas Portnoi, Elena Background: Folliculo-stellate cells were first identified with electron microscopy as a non-hormone secreting accessory cells, star-shaped and follicleforming cells. They represent about 4-20% of pituitary cells from the anterior pituitary lobe. The folliculo-stellate cells control several anterior pituitary activities. However, they do not produce hormones, but they produce growth factors, cytokines, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), leukemia inhibitory factor (LIF), IL-6, and macrophage migration inhibitory factor (MIF), IL-1β and TNF-α. Regardless of a long period of pituitary research and many morphological, cytophysiological studies, it has been reported that a precise understanding of the major functions of folliculo-stellate in the pituitary gland remains unknown. Consequently, there are still many unsolved issues. Conclusions: This article intends to review the characteristics of folliculo-stellate cells and their uncertain functions in the adenohypophysis, such as their importance as stem cells, in the process of maturation and aging. New researches about the origin and differentiation of folliculo-stellate cells may provide many relevant answers about physiopathology of the pituitary gland and the pathogenesis of pituitary tumors, as well as their influence on the quality of life. Immunohistochemical profile studies of folliculo-stellate cells in pituitary gland, can be useful in elucidation of morphological features and may have a predictive role for the early identification of pituitary microadenomas, prognosis of pituitary tumors and treatment. Department of Morphopathology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau the Republic of Moldova

2020-01-01T00:00:00Z Placinta, Gheorghe Pantea, Victor Cojuhari, Lilia Cebotarescu, Valentin Placinta, Lidia Croitoru, Dan http://repository.usmf.md:80/xmlui/handle/20.500.12710/11701 2021-09-22T15:14:38Z 2020-01-01T00:00:00Z

Interaction between SARS-CoV-2 and human organism Placinta, Gheorghe; Pantea, Victor; Cojuhari, Lilia; Cebotarescu, Valentin; Placinta, Lidia; Croitoru, Dan Background: COVID-19 is a part of the betacoronaviridae group, sabercoviridae subgroup. At the moment we are confronting a pandemy, which has a completely new pathologic pattern for the whole world. Considering the highly contagious characteristics of the virus, which is the cause of death for many people, and also the fact that many people continue to be infected with this virus there is a stringing necesity of combating this pandemy. Because of that we need the knowledge that regards the physiopathologic mechanisms, particularities of the host-invader interactions, relevance of asymptomatic forms, explanations of the evolving divergencies, posibility of recurrent infections, clinical signs, comorbidities that harshen this pathology, pharmacologic agents that are effective to fight the infection and immune mechanisms of defense in the organism. A great importance is given for the identification of the intial criteria needed for a prognostic, to prevent the critical forms of pathology and to set the parameters for the severity indicators. Conclusions: The research in the field of SARS-CoV-2 requires the gathering of the databases that are related to the investigated persons, to establish the clinico-evolutive differences for the COVID-19 patients according to many factors that could influence the course of the disease. An important difference is the identification of early signs and prevention of the critical disease forms, by extending the laboratory investigations, establishing the parameters for severity indicators through determining the degree of the immune response. Department of Infectious Diseases, Department of Infectious Diseases, Tropical and Medical Parasitology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova

2020-01-01T00:00:00Z Otgon, Ana Lisii, Leonid http://repository.usmf.md:80/xmlui/handle/20.500.12710/11700 2021-09-22T15:14:53Z 2020-01-01T00:00:00Z

Actualities of disproportionate affection of women vs men in Alzheimer’s disease Otgon, Ana; Lisii, Leonid Background: Alzheimer’s disease (AD) is a neurodegenerative disease of the elderly, being recognized worldwide as the most common cause of dementia. However, the harm generated by this disease to women and men is disproportionate, in women the disease is recorded twice as much. Numerous research studies have tried to find an answer regarding the causes of this disproportionality. So far, some fundamental differences between macroscopic, microscopic and biochemical structures of female vs. male brain have been investigated. First of all, emphasis was placed on macroscopic structural differences. In this study, a particular role was attributed to APOE4 gene which was shown to be an increased risk factor of AD in women who possess this allele. Hormonal changes in women, such as decreased postmenopausal estrogen, greatly influence disease incidence and prevalence. All these factors tell about the increased susceptibility of women to this disease. However, the definite mechanisms of this disease are incompletely elucidated and further studies are needed. Conclusions: The identification of pathobiochemical mechanisms based on gender, that influence the incidence and prevalence of Alzheimer’s disease is essential. Thus, it could be a target in the development of effective preventive therapeutic strategies from the prodromal phase of the disease. In this context, the development of personalized treatment according to gender specifics should be considered in future. Department of Biochemistry and Clinical Biochemistry Nicolae Testimitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova

2020-01-01T00:00:00Z