http://repository.usmf.md:80/xmlui/handle/20.500.12710/449 2026-04-19T07:08:47Z 2026-04-19T07:08:47Z Preguza, Ion http://repository.usmf.md:80/xmlui/handle/20.500.12710/3528 2019-06-25T06:21:49Z 2009-01-01T00:00:00Z

Unele verigi patogenetice în producerea coagulării intravasculare diseminate Preguza, Ion Some pathogenetical links in generating of disseminated intravascular coagulation Disseminated intravascular coagulation (DIC) is a complex systemic thrombohemorrhagic disorder involving the generation of intravascular fibrin and the consumption of procoagulants and platelets. The resultant clinical condition is characterized by intravascular coagulation and hemorrhage. DIC is always secondary to an underlying disorder and is associated with a number of clinical conditions, generally involving activation of systemic inflammation. DIC is most commonly observed in severe sepsis and septic shock. DIC has several consistent components including activation of intravascular coagulation, depletion of clotting factors, and end-organ damage. Prognosis varies depending on the underlying disorder. The prognosis for those with DIC, regardless of cause, is often grim. The colloquial reference "death is coming," refers to the lack of existing and alternative forms of available treatment options, and to an expected worsening prognosis. Coagularea intravasculară diseminată (CID) este un sindrom complex care implică formarea fibrinei intravascular şi consumarea factorilor procoagulanţi şi a plachetelor sangvine. Tabloul clinic este determinat de prezenţa trombilor în vasele microcirculatorii, şi de sindromul hemoragic. Sindromul CID apare întotdeauna pe fundalul unei patologii de bază. Pronosticul pentru un pacient cu diagnosticul CID depinde de patologia de bază, dar de regula, este nefavorabil, din cauza lipsei alternativelor şi opţiunilor de tratament. Catedra Fiziopatologie şi Fiziopatologie Clinică USMF „Nicolae Testemiţanu”

2009-01-01T00:00:00Z Preguza, Ion http://repository.usmf.md:80/xmlui/handle/20.500.12710/3533 2019-06-25T06:21:49Z 2009-01-01T00:00:00Z

Unele verigi patogenetice în producerea coagulării intravasculare diseminate Preguza, Ion Disseminated intravascular coagulation (DIC) is a complex systemic thrombohemorrhagic disorder involving the generation of intravascular fibrin and the consumption of procoagulants and platelets. The resultant clinical condition is characterized by intravascular coagulation and hemorrhage. DIC is always secondary to an underlying disorder and is associated with a number of clinical conditions, generally involving activation of systemic inflammation. DIC is most commonly observed in severe sepsis and septic shock. DIC has several consistent components including activation of intravascular coagulation, depletion of clotting factors, and end-organ damage. Prognosis varies depending on the underlying disorder. The prognosis for those with DIC, regardless of cause, is often grim. The colloquial reference "death is coming," refers to the lack of existing and alternative forms of available treatment options, and to an expected worsening prognosis. Coagularea intravasculară diseminată (CID) este un sindrom complex care implică formarea fibrinei intravascular şi consumarea factorilor procoagulanţi şi a plachetelor sangvine. Tabloul clinic este determinat de prezenţa trombilor în vasele microcirculatorii, şi de sindromul hemoragic. Sindromul CID apare întotdeauna pe fundalul unei patologii de bază. Pronosticul pentru un pacient cu diagnosticul CID depinde de patologia de bază, dar de regula, este nefavorabil, din cauza lipsei alternativelor şi opţiunilor de tratament. Catedra Fiziopatologie şi Fiziopatologie Clinică USMF „Nicolae Testemiţanu”

2009-01-01T00:00:00Z Павловски, Яна Павловски, Дана http://repository.usmf.md:80/xmlui/handle/20.500.12710/3531 2019-06-25T06:21:49Z 2009-01-01T00:00:00Z

Молекулярные и физиологические механизмы старения Павловски, Яна; Павловски, Дана The analysis of basic conceptions of the origin of aging were presented in the article. There were exposed contemporary data about molecular, cellular and physiological mechanisms of aging, including the role of DNA damage and repair, of the telomere and telomerase, of the system of the growth hormone – insulin-like growth factor-1 and the development of the age-associated pathologies. În articolul dat sunt prezentate concepţii contemporane referitor la originea îmbătrânirii. Accentul se pune pe elucidarea mecanismelor moleculare, celulare şi fiziologice, care relevă îndeosebi rolul leziunilor, reparaţiei ADN-ului, a telomerilor şi telomerazelor, precum şi al sistemului format din hormonul creşterii şi factorul de creştere insulin-like I în procesul îmbătrânirii şi dezvoltării patologiilor asociate cu vârsta. Кафедра Патофизиологии и клинической патофизиологии

2009-01-01T00:00:00Z Chiriac, Ecaterina http://repository.usmf.md:80/xmlui/handle/20.500.12710/3532 2019-06-25T06:21:49Z 2009-01-01T00:00:00Z

Strategii de tratament biologic al cancerului Chiriac, Ecaterina Biological theory of cancer is a new way of treating cancer, its goal being the stimulation of the immune system in order to treat or prevent the apparition of tumors. Many strategies of biological treatment, such as cytokines, antitumoral vaccines, monoclonal antibodies, retinoides have already proved to be efficient by having a long-lasting action and only a few side-effects. Nowadays, the problem of discovering some strategies, which would combine the methods of biological treatment with the traditional ones, for the improvement of life quality in patients with tumors, is being thoroughly discussed. Terapia biologică a cancerului este o nouă cale de tratare a cancerului, premisa căreia este stimularea sistemului imun în scopul tratării sau prevenirii apariţiei tumorilor. Numeroasele strategii de tratament biologic, aşa ca utilizarea citokinelor, vaccinurilor antitumorale, anticorpilor monoclonali, retinoizilor şi-au demonstrat eficacitatea, avînd un efect durabil şi puţine efecte adverse. În prezent se pune problema elaborării unor strategii de combinare a metodelor de tratament biologic cu cele tradiţionale în scopul ridicării calităţii vieţii pacienţilor. Catedra Fiziopatologie şi Fiziopatologie clinică USMF “Nicolae Testemiţanu”

2009-01-01T00:00:00Z