ARTICOLE ȘTIINȚIFICE

Embolia pulmonară acută asociată cu tromboza acută a sistemului venos profund

2026-06-03T07:47:26Z

Embolia pulmonară acută asociată cu tromboza acută a sistemului venos profund Ranga, Doina; Caproş, Natalia; Caproș, Hristiana Scopul studiului a fost prezentarea unui caz clinic de EP la o pacientă tânără de 26 de ani cu o scurtă trecere în revistă a literaturii de specialitate. Particularitatea cazului cu embolie pulmonară prezentat a fost asocierea cu tromboza acută a sistemului venos profund și venei externe pe fon de anamnestic de utilizare a contraceptivelor orale combinate.; The purpose of the study was to present a clinical case of pulmonary embolism in a young patient of 26 years, with a brief review of the literature. The particularity of the presented case with the pulmonary embolism was the association with the acute thrombosis of the deep venous system venous system on background of combined oral contraceptives use.; Целью исследования было представить клинический случай легочной эмболии у молодой пациентки 26 лет с кратким обзором литературы. Особенностью случая с представленной легочной эмболией стала связь с острым тромбозом глубокой венозной системы и наружной вены, бедренных вен, подколенных вен, большеберцовых вен на фоне применения комбинированных оральных контрацептивов.

Tromboembolism pulmonar subclinic în contextul patologiei cardiovasculare: caz clinic

2026-06-03T07:38:06Z

Tromboembolism pulmonar subclinic în contextul patologiei cardiovasculare: caz clinic Țelinschii, Artemie; Medvedeva, Ecaterina; Sîrbu, Adelina; Ranga, Doina; Matcovschi, Sergiu; Corlăteanu, Olga; Talmaci, Cornelia; Caproş, Natalia Scopul studiului a fost să prezentăm un caz de bărbat în vârstă de 72 de ani cu tromembolism pulmonar în contextul patologiei cardiovasculare. Acest raport de caz subliniază importanța diagnosticării și tratamentului precoce pentru a evita consecințe fatale. Identificarea tromboembolismului pulmonar în cazurile de patologie cardiovasculară poate fi complexă din cauza suprapunerii simptomatologiei, influenței tratamentului asupra testelor diagnostice și dificultăților de interpretare ale investigațiilor imagistice.; The aim of the study was to present a case of a 72-year-old man with pulmonary thromboembolism in the context of cardiovascular pathology. This case report highlights the importance of early diagnosis and treatment to prevent fatal outcomes. Identifying pulmonary thromboembolism in cases of cardiovascular pathology can be challenging due to overlapping symptoms, the influence of treatment on diagnostic tests, and difficulties in interpreting imaging investigations.; Целью исследования было представить случай 72-летнего мужчины с легочным тромбоэмболизмом на фоне сердечно-сосудистой патологии. Этот клинический случай подчеркивает важность ранней диагностики и лечения для предотвращения фатальных исходов. Выявление легочного тромбоэмболизма в случаях сердечно-сосудистой патологии может быть сложным из-за пересечения симптомов, влияния лечения на диагностические тесты и трудностей в интерпретации данных визуализации.

Trombembolism pulmonar la femei in menopauză: prezentare de caz

2026-06-03T07:37:55Z

Trombembolism pulmonar la femei in menopauză: prezentare de caz Ranga, Doina; Şveţ, Svetlana; Cealan, Andrei; Matcovschi, Sergiu; Sîrbu, Ion; Caproş, Hristiana; Talmaci, Cornelia; Caproş, Natalia Studiul de față prezintă cazul unei paciente de 73 de ani, cu multiple comorbidități cardiovasculare. Particularitățile cazului prezentat sunt: simptome nespecifice și adresare tardivă cu evoluție dramatică, deși s-a instituit tratamentul complex, inclusiv anticoagulant. Studiile incluse în analiza literaturii au vizat următoarele: incidența și severitatea TEP la femei versus bărbați, rolul comorbidităților cu impact pe riscul de TEP, diferențele în utilizarea trombolizei.; This study presents the case of a 73-year-old female patient with multiple cardiovascular comorbidities. The case’s particularities include nonspecific symptoms, delayed presentation, and a dramatic outcome despite the implementation of complex treatment, including anticoagulation. The literature review focused on the following aspects: the incidence and severity of PE in women versus men, the role of comorbidities in influencing PE risk, and differences in thrombolysis usage.

Frailty syndrome in heart failure: from definition to biomarkers

2025-11-04T16:25:50Z

Frailty syndrome in heart failure: from definition to biomarkers Ivanes, Anastasia A.; Vetrilă Snejana, Boris; Grib, Livi T. Background. In an aging society, ensuring quality of life has become a major public health priority. Rising life expectancy and the high prevalence of cardiovascular risk factors have contributed to a global increase in heart failure (HF), currently affecting over 64 million people. At the same time, frailty syndrome (FS) – once considered a condition of the elderly – is now recognized in younger adults as well, categorized as early frailty (<65 years) and late frailty (≥65 years). FS is a multidimensional condition characterized by diminished physiological reserves and increased vulnerability to stressors, which significantly contributes to disability, hospitalizations, and mortality among patients with HF. This review aims to synthesize recent evidence on the definition, assessment, and prognostic value of biomarkers related to FS in individuals with HF. Materials and methods. This review analyzes 10 peer-reviewed studies published between 2022 and 2025, selected from PubMed, NCBI, and Google Scholar. The selected articles focused on frailty in the context of HF, including clinical definitions, diagnostic tools, and relevant biomarker profiles. Results. The concept of frailty has evolved from the Fried physical phenotype model to broader frameworks encompassing physical, psychosocial, and cognitive domains. Biomarkers with diagnostic and prognostic relevance in FS include inflammatory markers (IL-6, TNF-α, CRP), oxidative stress indicators, hormonal decline markers (testosterone, DHEA-S), and sarcopenia-related markers (myostatin, serum creatinine). Moreover, emerging research areas – such as adiponectin levels, epigenetic regulation, and gut microbiota composition – have been implicated in the pathophysiology of frailty in HF. Conclusions. Frailty syndrome is a major determinant of adverse outcomes in patients with HF, regardless of age. The identification of specific biomarkers offers promising avenues for early diagnosis, individualized risk stratification, and targeted interventions. Integrating biomarker-based assessments into routine clinical practice could enhance prognostic precision and alleviate the healthcare burden associated with HF and frailty.