http://repository.usmf.md:80/xmlui/handle/20.500.12710/821 2026-04-04T19:01:14Z 2026-04-04T19:01:14Z Strukov, A. Serov, V. http://repository.usmf.md:80/xmlui/handle/20.500.12710/27815 2024-09-16T10:53:48Z 1999-01-01T00:00:00Z

Anatomia patologică Strukov, A.; Serov, V.

1999-01-01T00:00:00Z Zota, Ieremia Vataman, Vladimir http://repository.usmf.md:80/xmlui/handle/20.500.12710/2004 2024-09-16T10:41:53Z 2010-01-01T00:00:00Z

Morfopatologie generală Zota, Ieremia; Vataman, Vladimir

2010-01-01T00:00:00Z Zota, Ieremia Burkes, Ernest Jefferson Vataman, Vladimir http://repository.usmf.md:80/xmlui/handle/20.500.12710/2003 2024-09-16T10:28:56Z 2004-01-01T00:00:00Z

General morphopathology: a compendium and atlas Zota, Ieremia; Burkes, Ernest Jefferson; Vataman, Vladimir

2004-01-01T00:00:00Z Melnic, Eugen http://repository.usmf.md:80/xmlui/handle/20.500.12710/2002 2019-06-22T14:06:27Z 2015-01-01T00:00:00Z

The influence of the tumoral cell proliferation rate in pituitary adenoma on expressing other factors with a prognostic role and therapeutic potential Melnic, Eugen Background: This article describes the growth rate of pituitary adenomas, their invasion and potential recurrence. Some of them grow rapidly while others remain in a dormant condition for a long time. The recurrence rate is also very hard to forecast. The pituitary adenomas that initially reduced their proliferation rate now acquire a rapid one, producing aggressive recurrences. Materials and methods: Eighty two cases of pituitary adenomas were studied. The classification of human pituitary adenomas has been profoundly assisted by immunohistochemistry. Ki-67 antibody was used to assess the proliferative index of pituitary adenomas. Results: Acidophil type adenomas or acidophil cells areas within mixed pituitary adenomas had the highest proliferation rate. Chromophobe pituitary adenomas were Ki67 negative in 90%, as well as the ones that presented the basophilic cells. The pituitary adenomas with a trabecular growth pattern had the lowest rate of proliferation, in about 50% of the cases being zero. The heterogeneity expression of growth factors and corresponding receptors is dependent on hormonal profile of pituitary adenomas. Conclusion: The pituitary adenomas proliferation rate depends on the type of secreted hormone as well as on the hormonal associations met in some cases of pituitary adenomas. Department of Morphopathology, Nicolae Testemitsanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova

2015-01-01T00:00:00Z