Curierul Medical, 2016, Vol. 59, No 2

Curierul medical. April 2016, Vol. 59, No 2

2016-01-01T00:00:00Z

Curierul medical. April 2016, Vol. 59, No 2 From its debut in 1958, the journal has striven to support the interests of Moldovan medicine concerning the new concepts of its development. The Editorial Board warmly welcomes both the readers of and the authors for the journal, all those who are enthusiastic in searching the new and more effective ways of solving numerous medical problems. We hope that those who want to make their contribution to the science of medicine will find our journal helpful and encouraging. The journal is accredited by the National Council for Accreditation and Attestation. The journal publishes official papers, scientific articles, editorials, clinical studies and cases, lectures, methodological guides, reviews, brief reports, and correspondence. The journal welcomes articles in English, Romanian and Russian. The journal editorial policy provides the prompt publication of papers within 12 weeks after receiving them.; De la prima apariţie în 1958, revista susţine şi dezvoltă noile idei în domeniul medicinii, în Republica Moldova. Colegiul de redacţie agrează cu multă consideraţie atât cititorii cât şi autorii articolelor, pe toţi acei care cu mult entuziasm caută noi şi mult mai efective metode de soluţionare a multiplelor probleme ale medicinii. Sperăm, că toţi acei care doresc să-şi aducă aportul la dezvoltarea ştiinţelor medicale, vor găsi revista noastră utilă şi atractivă. Revista este acreditată de către Consiliul Naţional de Acreditare şi Atestare. Revista publică comunicări oficiale şi, totodată, sunt editate diverse publicaţii, inclusiv independente: articole ştiinţifice, editoriale, cercetări şi prezentări de cazuri clinice, prelegeri, îndrumări metodice, articole de sinteză, relatări scurte, corespondenţe şi recenzii. Revista publică articole în limba engleză, română şi rusă. Politica de editare a revistei prevede examinarea operativă şi publicarea articolelor timp de 12 săptămâni după înaintare.; С первого дня своего выпуска в 1958 году журнал стремится поддерживать и развивать новые идеи в области медицины в Молдове. Редакционная коллегия всегда рада как читателям, так и авторам статей, всем тем, кто с энтузиазмом ищет новые, более эффективные способы решения многочисленных задач медицины. Мы надеемся, что все те, кто хотят внести свой вклад в медицинскую науку, найдут наш журнал полезным и вдохновляющим. Журнал аккредитован Высшей Аттестационной Комиссией Республики Молдова. В журнале печатаются официальные материалы, научные статьи, наблюдения из клинической практики, обобщающие статьи, краткие сообщения, методические указания, рецензии и корреспонденция. В журнале публикуются статьи на английском, румынском и русском языках. Издательская политика журнала предусматривает оперативное рассмотрение и публикацию статей в среднем в течение 12 недель после поступления. Fondatori: Ministerul Sănătăţii al Republicii Moldova, Universitatea de Stat de Medicină şi Farmacie “Nicolae Testemiţanu”

Vasilii Chekurin – 125 years since the date of the birth

2016-01-01T00:00:00Z

Vasilii Chekurin – 125 years since the date of the birth Ababii, Ion; Cabac, Vasile; Maniuc, Mihai; Sandu, Alexandru

Influence of new Schiff bases and their combinations with 3d metals on the glutathione and thiol-disulfide metabolism in the liver in physiological conditions

2016-01-01T00:00:00Z

Influence of new Schiff bases and their combinations with 3d metals on the glutathione and thiol-disulfide metabolism in the liver in physiological conditions Andronache, Lilia Background: Glutathione and glutathione metabolism enzymes are essential for the normal functioning of cells and tissues and maintenance of body homeostasis. The aim of our study was to investigate the influence of the new Schiff bases, and their combinations with 3d metals, on the glutathione metabolism in the liver in physiological conditions. Material and methods: An experimental study of laboratory animals (rats) was performed. New local biologically active compounds (BAC) – CMD-4, CMD-8 and CMJ-23, were injected to healthy rats for 14 days. The content of glutathione (total, reduced and oxidized) and the activity of glutathione reductase (GR), glutathione peroxidase (GPO), glutathione-S-transferase (GST) and glutaredoxin (GRX) were determined in the liver homogenates. results: All tested BAC statistically significant decreased the level of reduced and total glutathione (about 20-30%), and GMJ-23 also reduced the oxidized glutathione in the liver (-48%, p<0.05). Influence on the activity of enzymes of glutathione metabolism was more ambiguous. Administration of CMD-4, CMD-8 and CMJ-23 did not produce conclusive changes of the enzyme activity of the glutathione metabolism, and their induction had only tendency of GR, GST and GRX activity decrease, while CMT-28 and CMT-67 preferentially modulated the activity of enzymes. conclusions: Local BAC exerts an individual influence on the glutathione metabolism in physiological conditions, which may be used for a particular regulation of the processes according to the cell needs.

Structural peculiarities of the maxilla and its surfaces in the perinatal period of ontogenesis

2016-01-01T00:00:00Z

Structural peculiarities of the maxilla and its surfaces in the perinatal period of ontogenesis Slobodian, Оlexandr М.; Korchynska, Natalia S. Background: Congenital clefts of the upper lip and palate are not more often as a part of this or that syndrome, but as an independent congenital disease in the form of an isolated developmental defect of separate organs. Therefore, it is necessary to detect and systematize peculiarities of the development and structure of the maxilla and its body in the perinatal period of ontogenesis. Material and methods: The study was conducted on 53 dead 4-10-month fetuses and 11 newborns (5 isolated organ complexes in particular) of both sexes without external signs of anatomical defects or abnormalities and without vivid macroscopic deviations from the normal structure of the skull. Before the beginning of the craniometric examination every specimen was fixed in craniostat in the horizontal auricular-ocular plane, in so-called “Frankfurt horizontal line”. All the measurements on the skulls were made by means of a tape measure, caliper, slide compasses and dial calipers. results: With the age of fetuses a short and wide shape of the upper jaw changes into a high and narrow one. The absence of the zygomatic-cellular crest is a characteristic sign of the fetuses of all the age groups and newborns. During perinatal period of ontogenesis infraorbital opening is usually projected in the point of crossing of the line connecting a lateral angle of the eye with the wing of the nose and the line passing from the medium angle of the eye to the angle of the mouth. conclusions: A typical shape of the maxilla during the perinatal period is short and wide found in early fetuses (4-5 month) – in 94% of cases, in fetuses of 6-7 months of age – in 82% and in fetuses of 8-10 months of age (late fetuses) – in 68% and newborns. A typical shape of the anterior surface of the maxilla for early fetuses is irregular trapeziform, and for 6-7-month fetuses, late fetuses and newborns – an elongated triangle shape.