http://repository.usmf.md:80/xmlui/handle/20.500.12710/13577 2026-07-28T04:14:26Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/16255 The Moldovan Medical Journal. February 2017, Vol. 60, No 1 The journal was founded in 1958 on the initiative of Nicolae Testemitsanu, an outstanding expert in orthopedics, social medicine, and public health. Now the publisher of the journal is the Scientific Medical Association of Moldova and the journal has become the scientific peer-reviewed periodical Edition designed for specialists in the areas of medicine, dentistry, pharmacy, social medicine, and public health. From its debut the journal has striven to support the interests of Moldovan medicine concerning the new concepts of its development. The aim of the Moldovan Medical Journal is to provide the international community with the results of scientific researches performed in the medical institutions of Moldova and inform Moldovan medical society about the advanced achievements of medicine abroad. The Editorial Board warmly welcomes both the readers of and the authors of the journal, all those who are enthusiastic about searching for new and more effective ways of solving numerous medical problems. We hope that those who want to make their contribution to the science of medicine will find our journal helpful and encouraging. Fondatori: Ministerul Sănătăţii al Republicii Moldova, Universitatea de Stat de Medicină şi Farmacie “Nicolae Testemiţanu” 2017-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/2729 Experimental study of new 3-(2-R1 -6-R2 -4-oxyquinoline-3(4H)-yl)alkyl (alkaryl-, aryl) carboxylic acid derivative (PC-66 compound) Kramar, Hanna Background: Screening studies have revealed in new 3-(2-R1-6-R2-4-oxyquinoline-3(4H)-yl)alkyl (alkaryl-, aryl) carboxylic acid derivative (PC-66 compound) expressive analgesic properties without any damaging effects on the stomach. Therefore, in-depth study of the pharmacological properties of PC-66 compound as a pain management agent is considered topical. Objective of the study – to evaluate a pain-killing effect of PC-66 compound compared to ketorolac and diclofenac sodium on various rat pain models. Material and methods: In experiments on 101 Wistar male rats (180-210 g) of somatic model (tail-flick) and neuropathic pain model (ligation of the sciatic nerve), and formalin test (5% formalin solution, 0.1 ml subplantarly) we investigated the antinociceptive activity of the PC-66 compound (1.0 mg/ kg) versus ketorolac (2.4 mg/kg) and diclofenac (4.0 mg/kg) administered intraperitoneally. Results: In the tail-flick model, PC-66 compound presented significant growth of PT at Hour 1 and Hour 2 by 40.6% and 50.6%, respectively. The analgesia effect of the test compound was superior to the one of diclofenac sodium, but inferior to ketorolac at Hour 1 and Hour 2, yet surpassed it by duration of action. In the formalin test model, analgesic effect of compound PC-66 was the most evident in the first (central) phase, and slightly changed the latent period and duration of the second phase of the test, while diclofenac mostly influenced Phase II (inflammatory) of the formalin test. In the model of neuropathic pain, compound PC-66 also demonstrated pronounced pain-killing effect: PT of subject rat limb grew on average by 46.7% in 2 hours following intraperitoneal administration. For this activity, PC-66 was slightly inferior to ketorolac, which caused PT growth by 51.9%. Conclusions: new 3-(2-R1-6-R2-4-oxyquinoline-3(4H)-yl) alkyl (alkaryl-, aryl) carboxylic acid derivative (PC-66 compound) presented distinct analgesic effect both in somatic and neuropathic pain models. Department of Pharmacology, N. I. Pirogov National Medical University of Vinnitsa, Ukraine 2017-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/2730 Antimicrobial effect of biodegradable wound healing nano-containing polymer materials Popadyuk, Oleh Yaroslavovytch Background: Treatment of infected wounds presents the biggest difficulty for the surgeon. The treatment of skin lesions has recently increased due to the effect of developed local multi-application forms saturated with nano-sized antiseptic preparations, namely with metals nano-oxides: zinc oxide, magnesium oxide, iron oxide, silver oxide, etc. Material and methods: We have developed a biodegradable polymer film that is flexible and has the ability to biodegrade and deliver the remedy to the area of injury. Saturated with active components, polymer films have been studied for their antimicrobial effect against clinical strains of opportunistic microorganisms commonly present in wounds, which were isolated from patients with purulent-septic diseases: Staphyloccus aureus, Staphyloccus epidermidis, Staphyloccus haemolyticus, Streptococcus pyogenes, Escherichia coli, Citrobacter freundii, Pseudomonas aeruginosa and Candida tropicalis yeasts. Results: The films saturated with zinc nano-oxide have been characterized by high antimicrobial effect against all used microbial cultures. Films containing 5 and 10% of ZnO appeared to produce larger areas of growth inhibition against the most strains in comparison to the films containing 1% of ZnO. In contrast to zinc nano-oxide, the presence of magnesium in films hasn’t proved to have any antimicrobial effect. Conclusions: Biodegradable films with 5% of nano-oxide content have optimal antimicrobial effect in vitro against relatively opportunistic microorganisms and require further experimental and clinical studies. Department of General Surgery, National Medical University of Ivano-Frankivsk, Ukraine 2017-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/2732 Infravesical urinary tract obstruction and transurethral endoscopic approach of treatment Ghicavii, Vitalii Backqround: The results of scientifical progress in recent years have contributed to the development of transurethral endoscopic surgery, with the implementation of new methods, less invasive, for the treatment of the lower urinary tract diseases of different genesis. Laser surgery, transurethral electorezection, electrovaporization, bipolar surgery (plasmakinetic rezection and vaporization) and the combination of these methods have a number of avantages over traditional open interventions and contribute to a significant change in the treatment approach of most urological diseases, including those causing infravesical obstruction (IVO). Conclusions: The implementation of personalized medicine with correct selecting and pathogenetic motivation of the methods of treatement in management of the IVO have been made in several directions: prophylactics, diagnosis and treatment. Medical and social importance, variety of clinic manifestations and evolution, evident alternation of quality of life, high cost of diagnostic, conservative management and of surgical treatment determine the statuts of infravesical obstruction as a current problem from scientific and practical point of view and motivates the need of a deep study of disorders manifested through IVO, minimizing complications and the rate of their relapse. Department of Urology and Surgical Nephrology, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova 2017-01-01T00:00:00Z