http://repository.usmf.md:80/xmlui/handle/20.500.12710/33046 2026-09-06T03:07:43Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/33579 “Ankylosing spondylitis – an old disease with new perspectives”. Author: Lia Chișlari, MD, PhD, associate professor Revenco, Ninel 2026-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/33577 Professor Valeriu Revenco at 70 – a life dedicated to excellence in cardiology Grib, Livi 2026-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/33557 Proteus syndrome in a young African woman: a clinically diagnosed ultra-rare mosaic overgrowth disorder Voloc, Chiril; Olaru, Andrei; Rusu, Irina; Revenco, Ninel; Voloc, Alexandru Proteus syndrome is an extremely rare congenital multisystem disorder characterized by highly variable clinical manifestations. Its exact prevalence remains unknown, with fewer than 200 cases reported in the medical literature worldwide. Clinical case description. We report the case of an 18-year-old African woman diagnosed with Proteus syndrome, presenting with marked asymmetrical overgrowth affecting the upper limbs, trunk, and lower limbs. The distribution of the deformities resembled the appearance of a tree trunk with multiple stumps. Additionally, the patient exhibited soft tissue tumor-like formations at the left oral commissure and in the left retroauricular region. Conclusion. The detailed phenotypic description of individuals with Proteus syndrome is essential due to the extreme rarity and clinical complexity of this disorder. Improved awareness and diagnostic acumen among healthcare professionals are critical for the early identification and appropriate multidisciplinary management of affected patients. Given the high risk of life-threatening complications, such as the development of malignant tumors and thromboembolic events, a structured and dynamic follow-up protocol is required. Moreover, the psychosocial dimension of the disease must not be overlooked. Many patients experience profound emotional distress, stigmatization, and moral suffering, which can significantly impact their quality of life. An integrated approach that combines medical surveillance with psychological and social support is imperative for optimizing long-term outcomes in Proteus syndrome. 2026-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/33556 Psoriasis vulgaris and B-cell non-Hodgkin lymphoma: a complex case with rare cephalic localization Rotari, Mihaela; Bețiu, Mircea; Buruiană, Sanda; Pînzaru, Valeria; David, Valeriu; Șaptefrați, Lilian Introduction. Psoriasis is a chronic immune-mediated inflammatory condition and is considered a potential risk factor for the development of hematologic malignancies, particularly in the context of immunosuppressive therapy and T-cell dysfunction. B-cell non-Hodgkin lymphomas are neoplasms of the lymphatic system with variable clinical manifestations, most commonly presenting with peripheral lymphadenopathy. Primary localization in the soft tissues of the head, with bone invasion, is rare. Case presentation. We report a rare case of cephalic aggressive NHL Not Otherwise Specified (NOS) in a 63-year-old patient with a history of psoriasis vulgaris and Clear cell carcinoma (T1N0M0, treated in 2021 at the Oncology Institute in Chișinău), who presented with a painless right temporo-parietal mass. MRI revealed a 48×19×50 mm lesion in the temporal soft tissues with extension into the frontal bone. Surgical biopsy and immunohistochemistry (CD20+, CD79a+, CD45+, BCL6-) confirmed the diagnosis of B-cell NHL NOS. In 2022, the patient received 8 induction cycles of immunochemotherapy followed by maintenance therapy with Rituximab. PET/CT evaluation showed a Deauville score of 3, indicating a partial favorable response. Associated comorbidities (psoriasis, type 2 diabetes mellitus, hypertension) required multidisciplinary monitoring. Conclusions. This case illustrates an unusual cranial localization of aggressive B-cell lymphoma NOS and highlights the potential link between psoriasis and lymphoproliferative risk, as previously suggested in the medical literature. 2026-01-01T00:00:00Z