http://repository.usmf.md:80/xmlui/handle/20.500.12710/600 2026-04-25T02:49:31Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/23124 Taraxacum officinale roots acts as a powerful antioxidant Fulga, Ala; Protopop, Svetlana; Gudumac, Valentin; Tagadiuc, Olga 2022-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/13061 The effects of controlled reperfusion on oxidative lesions in ovarian torsion Lazăr, Cornelia VII International medical and pharmaceutical congress of students and young scientists, Chernivtsi, 2020 2020-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/13060 Are nowadays laboratory indices useful in ovarian torsion? Lazăr, Cornelia VII International medical and pharmaceutical congress of students and young scientists, Chernivtsi, 2019 2019-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/13059 Controlled reperfusion and oxidative stress-induced lesions in experimental ovarian torsion/detorsion Lazăr, Cornelia; Tagadiuc, O.; Misina, A.; Vozian, M.; Pantea, V. Ovarian torsion (OT), being a medical emergency, requires being correctly treated in the early stages of the disease, because reperfusion (R) injury may worsen existing lesions, leading to ovarian loss. The purpose of our study was to investigate the advanced oxidation protein products (AOPP) changes in rats’ serum subjected to different OT/detorsion models. Materials and methods. 70 healthy female rats (Rattus albicans), were randomized into 7 groups (n=10): nr. 1: healthy rats – no intervention; nr. 2: the sham group (laparotomy); nr. 3, 4 and 5 – OT for 3 hours and 3 hours ischemia with 1 hour R or 1 hour “on-off “ R; nr. 6 and 7: 3 hours OT and 24 hours R or 24 hours “on-off “ R. The “on- off method”: controlled R by opening and closing the clips that were applied on the ovarian annexes (on/off) in 10- seconds intervals, for a total of 120 seconds. AOPP level wàs measured in the blood serum samples by Capeillère-Blandin C., et al. method (2004). The results were analyzed by Welch’s ANOVA. Results. A statistically significant higher AOPP level was established in rats’ serum to 24 hours R following OT (mean±SE, 33,23±0,59 μM/L, p=0,001), compared with group nr. 1. The “on-off “ reperfusion method resulted in a decrease in AOPP, 24 hours after “on-off “ reperfusion (26,58±0,56 μM/L, p<0,001). Conclusions: “On-off” method of R minimizes the reperfusion injury in OT. Department of Biochemistry and Clinical Biochemistry, “Nicolae Testemitanu” State University of Medicine and Pharmacy Chisinau, Republic of Moldova; Department of Biochemistry and Clinical Biochemistry, “Nicolae Testemitanu” State University of Medicine and Pharmacy Chisinau, Republic of Moldova; Department of Surgical Gynecology, Mother and Child Institute Chisinau, Republic of Moldova; Department of Surgery nr.1 “Nicolae Anestiadi”, “Nicolae Testemitanu” State University of Medicine and Pharmacy Chisinau, Republic of Moldova; Laboratory of Biochemistry, “Nicolae Testemitanu” State University of Medicine and Pharmacy Chisinau, Republic of Moldova. 2017-01-01T00:00:00Z