http://repository.usmf.md:80/xmlui/handle/20.500.12710/24208 Mon, 27 Apr 2026 09:33:51 GMT 2026-04-27T09:33:51Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/24288 Revista de Științe ale Sănătății din Moldova = Moldovan Journal of Health Sciences. 2022, Vol. 30(4) Revista de Științe ale Sănătății din Moldova (Moldovan Journal of Health Sciences) a fost lansată în octombrie 2014. Aceasta este editată în limbile română și engleză, conform standardelor și ghidurilor internaționale actuale în domeniul științelor medicale, și are o apariție trimestrială. Revista este înregistrată în Instrumentul Bibliometric Național IBN/IDSI (nr.1 din 16.11.2015), iar din 21 decembrie 2017, prin Hotărârea Consiliului Suprem pentru Știință și Dezvoltare Tehnologică nr. 169, a fost inclusă în lista revistelor științifice de Tip B. Revista este înregistrată în 2 baze de date internaționale. Sat, 01 Jan 2022 00:00:00 GMT http://repository.usmf.md:80/xmlui/handle/20.500.12710/24288 2022-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/24287 Osteomyelitis of the jaws and facial bones caused by drug use (amphetamine, αpyrrolidinovalerophenone). Rusu-Radzichevici, Natalia Abstract. Introduction. An attempt was made to detect the pathogenetic factors involved in the occurrence of the disease by studying the clinical and laboratory data of 160 patients diagnosed with chronic osteomyelitis of the jaws treated in the clinic of oro-maxillo-facial surgery between 2005 and 2022. The patients studied were or are still drug users who use illicitly produced (amphetamine-type drugs) or other drugs (abbreviated α-PVP). We obtained positive results in the treatment of toxic osteomyelitis of the jaws following the implementation of a conservative and surgical treatment scheme. Materials and methods. Detailed anamnesis of disease development, clinical examination, pictures, an orthopantomogram, general blood analysis and biochemical profile, urine analysis, blood markers, and AIDS analysis. Results. The study of the composition of used substances is an important factor in the definition and development of the given disease’s cause and mechanism. According to the patient’s statement, this disease developed following the use of the amphetamine drug. This drug contained the main substance – ephedrine, and also red phosphorus and iodine, which accumulate and cause trophic changes. Almost all organisms’ systems are affected by amphetamine intoxication. Given that only surgical treatment has a small effect on any of the patients in this group, we devised a conservative presurgical treatment plan. We prescribe medication for these patients: detoxification of the body from drugs that cause spasm of small blood vessels and accumulate in bone tissue, causing necrosis. Lavages of the mouth cavity are performed daily, and necrectomy is eventually performed. Conclusions. Assistance to drug addicts with jaw necrosis is a demanding subject given that the majority of their population is unemployed and without insurance. According to unofficial data, there are only 5000 such patients in Chisinau. Sat, 01 Jan 2022 00:00:00 GMT http://repository.usmf.md:80/xmlui/handle/20.500.12710/24287 2022-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/24285 Pathogenetic correlation of severe sepsis and multiple organ dysfunction syndrome provoked by multiple infections in perinatal period of women Mihalcean, Luminita; Rotaru, Victoria; Titica, Elena Abstract. Introduction. Despite significant advances in diagnosis, medical management and antimicrobial therapy, sepsis in the puerperium remains an important cause of maternal morbidity and mortality. The abnormalities associated with the clinical syndrome of sepsis result from a nonspecific innate inflammatory response. This is due to the fact that sepsis represents a systemic inflammatory response syndrome (SIRS) to infection or injury; therefore, it can rapidly progress to septic shock and death despite aggressive treatment. Severe sepsis with MODS has a mortality rate of 20– 40%, rising to around 60% if septicemic shock develops. Symptoms of sepsis may be less distinctive than in the non-pregnant population and are not necessarily present in all cases; therefore, a high index of suspicion is necessary. The major pathogens causing sepsis in the puerperium are: group A streptococcus (GAS), also known as Streptococcus pyogenes, Escherichia coli, Staphylococcus aureus, Streptococcus pneumonia, methicillin-resistant S. aureus (MRSA), Clostridium septicum, Morganella morganii and antibiotic-resistant Stenotrophomonas Moltrophilia. Multiple risk factors for maternal sepsis have been identified: obesity, impaired glucose tolerance/diabetes, impaired immunity/immunosuppressant medication, anemia, vaginal discharge, history of pelvic infection, amniocentesis and other invasive procedures, cervical cerclage, prolonged spontaneous rupture of membranes, caesarean section, wound hematomas, retained products of conception, GAS infection, vaginal trauma. Material and methods. Presentation of case report using the following key-words: „infection”, „systemic inflammatory response syndrome (SIRS)”, „severe sepsis”, „septic shock”, „multiorgan dysfunction syndrome (MODS)”. Results. We present a case of perinatal infections complicated with MODS. Conclusions. The presence of pelvic hematomas triggers the sepsis caused by multiple infections in perinatal period and can significantly increase the morbidity related to bleeding, infection, surgery and blood product transfusion. The clinical situation may worsen in the presence of pre-existing pathological conditions before pregnancy. Sat, 01 Jan 2022 00:00:00 GMT http://repository.usmf.md:80/xmlui/handle/20.500.12710/24285 2022-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/24224 Osteitis condensans ilii – difficulty in diagnosis and management. Clinical case study Groppa, Liliana; Homițchi, Marinela; Stog, Valeria; Russu, Eugeniu; Chișlari, Lia; Bujor, Oxana; Taran, Lilea Abstract. Introduction. Osteitis condensans ilii (OCI) is a condition characterized by benign sclerosis of the iliac bone in the portion adjacent to the sacroiliac joints, which is radiologically manifested by triangular opacities at the level of this portion. Among the clinical manifestations, localized low back or lumbosacral pain is often attested, which is found in the gestational or post-partum period. The pain may worsen during physical exertion or during menstruation and may be accompanied by myalgia. Material and methods. The epidemiological, clinical and paraclinical data were used to highlight this study, followed by the conclusions of multidisciplinary specialists, retrieved from the inpatient medical records of 3 women with OCI, who were admitted for diagnosis and treatment. Results. 3 cases of imaging-determined OCI will be presented, which were initially diagnosed with seronegative spondyloarthritis (SpA). Through them, we would determine the varieties between the OIC forms and their differential diagnosis with SpA. The results of the lab tests do not reveal specific changes, so the markers of inflammation (C-reactive protein, erythrocyte sedimentation rate) were normal. Also, unlike SpA, the marker HLA-B27 is in most cases negative. Conclusions. According to the results of the presented clinical cases, OCI is often confused with sacroiliitis, which leads to misdiagnosing and erroneous treatment tactics. Thus, in order to establish a true diagnosis, it is necessary to collect a detailed history, perform a comprehensive objective examination, which includes the character of the pain and its triggers, the lack of inflammatory lab markers and the radiological presence of the sclerosis areas at the level of the iliac bone, not involving the sacroiliac joints. Sat, 01 Jan 2022 00:00:00 GMT http://repository.usmf.md:80/xmlui/handle/20.500.12710/24224 2022-01-01T00:00:00Z