http://repository.usmf.md:80/xmlui/handle/20.500.12710/245 Thu, 06 Aug 2026 14:00:20 GMT 2026-08-06T14:00:20Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/33502 Methods of diagnosis and interdisciplinary treatment of congenital edentations: Summary of the thesis of Doctor Habilitatus in Medical Sciences: 323.01 Dentistry Solomon, Oleg Thesis structure: The thesis comprises 206 pages and consists of an Introduction, three chapters, General Discussion, General Conclusions, and Practical Recommendations. It is illustrated with 9 tables, 102 figures, and 4 appendices, and includes a bibliography comprising 301 references. The research findings have been published in 78 scientific papers. Key words: congenital edentulousness, malformations, dento-maxillary apparatus, diagnosis, interdisciplinary treatment, clinical protocol. Field of study: Dentistry, congenital dentitions. The purpose of the paper: Evaluation of the sample, methodical identification of the diagnosis and interdisciplinary treatment in patients with congenital edentulous teeth. Objectives of the study: Evaluation of the epidemiological characteristics of patients with malocclusions associated with congenital dentitions. Highlighting the methods of early detection of congenital edentations. Elaboration of clinical and paraclinical diagnostic methods. The normal development of the multiple and complicated functions of the dento-maxillary apparatus in congenital edentations. The study and development of a predominantly interdisciplinary treatment of congenital edentations. The scientific novelty of the study: it consisted in the elucidation of the clinical particularities of congenital dentitions, taking into account their increasing incidence. For this purpose, an interdisciplinary clinical protocol was developed, as well as a survey of the group of patients predisposed to the appearance of congenital edentations, a study conducted for the first time in the Republic of Moldova. The scientific problem solved: the development of new diagnostic methods and the establishment of interdisciplinary treatment for patients with congenital edentulous teeth that will reduce the number of registered cases of this anomaly of the dento-maxillary apparatus among the population of the Republic of Moldova. The theoretical significance and the applied value of the study: The research results allowed revealing the clinical and paraclinical particularities of patients with congenital edentulousness and the possibilities of their interdisciplinary treatment. Carrying out an in-depth study of the parameters of congenital edentations, will significantly supplement the knowledge about this anomaly of the dento-maxillary apparatus, specific to the respective geographical region, the essential aspects that could determine the appearance and progression of the given pathology will be made known. Thu, 01 Jan 2026 00:00:00 GMT http://repository.usmf.md:80/xmlui/handle/20.500.12710/33502 2026-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/33501 Metodele de diagnostic și tratament interdisciplinar al edentațiilor congenital: Rezumatul tezei de doctor habilitat în științe medicale: 323.01 Stomatologie Solomon, Oleg Structura tezei: Lucrarea cuprinde 206 pagini și este constituită din: introducere, 3 capitole, discuții generale, concluzii generale și recomandări practice. Teza este ilustrată cu 9 tabele, 102 figuri și 4 anexe., indicie bibliografic (301 de titluri). Rezultatele obținute sunt publicate în 79 lucrări științifice. Cuvintele – cheie: edentații congenitale, malformații, aparat dento-maxilar, diagnostic, tratament interdisciplinar, protocol clinic. Domeniul de studiu: Stomatologie, edentații congenitale. Scopul lucrării: Evaluarea eșantionului decercetare, identificarea metodică a diagnosticului și tratamentul interdisciplinar la pacienții cu edentații congenitale. Obiectivele studiului: 1. Evaluarea particularităților epidemiologice a pacienților cu malocluzii asociate cu edentații congenitale. 2. Evidențierea metodelor de depistare precoce a edentațiilor congenitale. 3. Elaborarea metodelor de diagnostic clinic și paraclinic. 4. Desfășurarea normală a funcțiilor multiple şi complicate ale aparatului dento-maxilar în edentațiile congenitale. 5. Studiul și elaborarea unui tratament predominant interdisciplinar al edentațiilor congenitale. Noutatea științifică a studiului: a constat în elucidarea particularităților clinice ale edentațiilor congenitale, luând în considerare incidența tot mai crescută a acestora. În acest scop, a fost elaborat un protocol clinic interdisciplinar, cât și un sondaj al grupului de pacienți predispuși la apariția edentațiilor congenitale, studiu efectuat pentru prima dată în Republica Moldova. Problema științifică soluționată: elaborarea noilor metode de diagnostic și stabilirea tratamentului interdisciplinar la pacienții cu edentații congenitale care vor reduce numărul cazurilor înregistrate a acestei anomalii a aparatului dento-maxilar în rândul populației din Republica Moldova. Semnificația teoretică și valoarea aplicativă a studiului: Rezultatele cercetării efectuate au permis relevarea particularităților clinice și paraclinice la pacienții cu edentații congenitale și posibilitățile de tratament interdisciplinar ale acestora. Realizarea unui studiu aprofundat a parametrilor edentațiilor congenitale, va suplini semnificativ cunoștințele despre aceste anomalii a aparatului dentomaxilar, specifică regiunii geografice respective, se vor face cunoscute aspectele esențiale care ar putea determina apariția şi progresarea patologiei date. Thu, 01 Jan 2026 00:00:00 GMT http://repository.usmf.md:80/xmlui/handle/20.500.12710/33501 2026-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/33500 Metodele de diagnostic și tratament interdisciplinar al edentațiilor congenitale: Teză de doctor habilitat în științe medicale: 323.01 Stomatologie Solomon, Oleg Structura tezei: Lucrarea cuprinde 233 pagini și este constituită din: introducere, 3 capitole, discuții generale, concluzii generale și recomandări practice. Teza este ilustrată cu 9 tabele, 102 figuri și 4 anexe., indicie bibliografic (301 de titluri). Rezultatele obținute sunt publicate în 79 lucrări științifice. Cuvintele – cheie: edentații congenitale, malformații, aparat dento-maxilar, diagnostic, tratament interdisciplinar, protocol clinic. Domeniul de studiu: Stomatologie, edentații congenitale. Scopul lucrării: Evaluarea eșantionului decercetare, identificarea metodică a diagnosticului și tratamentul interdisciplinar la pacienții cu edentații congenitale. Obiectivele studiului: 1. Evaluarea particularităților epidemiologice a pacienților cu malocluzii asociate cu edentații congenitale. 2. Evidențierea metodelor de depistare precoce a edentațiilor congenitale. 3. Elaborarea metodelor de diagnostic clinic și paraclinic. 4. Desfășurarea normală a funcțiilor multiple şi complicate ale aparatului dento-maxilar în edentațiile congenitale. 5. Studiul și elaborarea unui tratament predominant interdisciplinar al edentațiilor congenitale. Noutatea științifică a studiului: a constat în elucidarea particularităților clinice ale edentațiilor congenitale, luând în considerare incidența tot mai crescută a acestora. În acest scop, a fost elaborat un protocol clinic interdisciplinar, cât și un sondaj al grupului de pacienți predispuși la apariția edentațiilor congenitale, studiu efectuat pentru prima dată în Republica Moldova. Problema științifică soluționată: elaborarea noilor metode de diagnostic și stabilirea tratamentului interdisciplinar la pacienții cu edentații congenitale care vor reduce numărul cazurilor înregistrate a acestei anomalii a aparatului dento-maxilar în rândul populației din Republica Moldova. Semnificația teoretică și valoarea aplicativă a studiului: Rezultatele cercetării efectuate au permis relevarea particularităților clinice și paraclinice la pacienții cu edentații congenitale și posibilitățile de tratament interdisciplinar ale acestora. Realizarea unui studiu aprofundat a parametrilor edentațiilor congenitale, va suplini semnificativ cunoștințele despre aceste anomalii a aparatului dento-maxilar, specifică regiunii geografice respective, se vor face cunoscute aspectele esențiale care ar putea determina apariția şi progresarea patologiei date.; Thesis structure: The thesis comprises 233 pages and consists of an Introduction, three chapters, General Discussion, General Conclusions, and Practical Recommendations. It is illustrated with 9 tables, 102 figures, and 4 appendices, and includes a bibliography comprising 304 references. The research findings have been published in 79 scientific papers. Key words: congenital edentulousness, malformations, dento-maxillary apparatus, diagnosis, interdisciplinary treatment, clinical protocol. Field of study: Dentistry, congenital dentitions. The purpose of the paper: Evaluation of the sample, methodical identification of the diagnosis and interdisciplinary treatment in patients with congenital edentulous teeth. Objectives of the study: Evaluation of the epidemiological characteristics of patients with malocclusions associated with congenital dentitions. Highlighting the methods of early detection of congenital edentancies. Elaboration of clinical and paraclinical diagnostic methods.. The normal development of the multiple and complicated functions of the dento-maxillary apparatus in congenital edentities. The study and development of a predominantly interdisciplinary treatment of congenital edentancies The scientific novelty of the study: it consisted in the elucidation of the clinical particularities of congenital dentitions, taking into account their increasing incidence. For this purpose, an interdisciplinary clinical protocol was developed, as well as a survey of the group of patients predisposed to the appearance of congenital edentations, a study conducted for the first time in the Republic of Moldova. The scientific problem solved: the development of new diagnostic methods and the establishment of interdisciplinary treatment for patients with congenital edentulous teeth that will reduce the number of registered cases of this anomaly of the dento-maxillary apparatus among the population of the Republic of Moldova. The theoretical significance and the applied value of the study: The research results allowed revealing the clinical and paraclinical particularities of patients with congenital edentulousness and the possibilities of their interdisciplinary treatment. Carrying out an in-depth study of the parameters of congenital edentations, will significantly supplement the knowledge about this anomaly of the dento-maxillary apparatus, specific to the respective geographical region, the essential aspects that could determine the appearance and progression of the given pathology will be made known. Thu, 01 Jan 2026 00:00:00 GMT http://repository.usmf.md:80/xmlui/handle/20.500.12710/33500 2026-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/33499 Multidimensional approach to chronic heart failure for the development of an individualized evaluation matrix: Summary of the habilitation thesis in medical sciences: 321.03 Cardiology Cabac-Pogorevici, Irina Structure of the thesis. The work comprises 228 pages of electronic text and is structured into: an introduction, six chapters of original research, conclusions and recommendations, a bibliographic index (369 titles), 65 figures, 36 tables and 16 annexes. The research findings have been presented in xx scientific publications. Keywords: heart failure, phenotyping, comorbidities, cardiac remodeling, advanced imaging, artificial intelligence, evaluation matrix, cardiovascular risk. Field of study: Cardiology. Purpose of the study. To elucidate the clinical-evolutionary features and management strategies of chronic heart failure through the integration of advanced echocardiographic techniques and artificial intelligence algorithms, with the aim of developing a individualized evaluation matrix. Objectives of the study. To describe the clinical, hemodynamic, biological and evolutionary characteristics of patients with chronic heart failure; to identify specific types and phenotypes of heart failure and analyze their clinical evolution; to assess the role of conventional and advanced echocardiography in diagnosis, risk stratification and follow-up; to evaluate the impact of comorbidities on clinical presentation, hemodynamics and outcomes; to analyze therapeutic strategies applied to heart failure patients in comparison with current international guidelines; to assess the contribution of artificial intelligence tools to risk stratification across different heart failure phenotypes; and to develop an integrated digital matrix for individualized management by combining clinical-hemodynamic parameters, advanced echocardiographic techniques and artificial intelligence algorithms. Scientific novelty and originality. The thesis investigates heart failure from a multidimensional perspective, integrating clinical data with advanced imaging and analytical methods, including multivariable modelling and unsupervised clustering. An original individualized evaluation matrix has been developed, capable of differentiating clinically relevant phenotypes and identifying patients at high risk. The study introduces an innovative model that correlates cardiac remodeling with comorbidities, biomarkers, and speckle-tracking parameters, achieving for the first time a systematic integration of clinical, metabolic and imaging indicators within a unified analytical architecture with direct applicability in risk stratification. The important scientific problem solved. The thesis establishes and validates a holistic model for assessing heart failure, enabling the definition of clinical phenotypes and the identification of patients at increased risk of hospitalization and mortality, thereby supporting individualized therapeutic decision-making. Theoretical significance. The findings elucidate contemporary mechanisms of heart failure evolution in the context of comorbidities and contribute to updating phenotyping concepts through the integration of imaging, clinical and functional markers. The work deepens understanding of the relationship between cardiac remodeling, ventricular dysfunction and the heterogeneity of disease phenotypes. Practical value. The developed evaluation matrix provides a practical tool for risk stratification, treatment individualization and optimization of clinical management. The results can be applied in professional training programs, clinical registries and the development of digital decision-support instruments. Implementation of results. The outcomes have been incorporated into the teaching and clinical activities of the Cardiology Departments of the “Nicolae Testemițanu” State University of Medicine and Pharmacy, in the clinical practice of the Institute of Cardiology, and in initiatives aimed at digitalizing cardiac patient evaluation, forming the basis for algorithmic prototypes for risk stratification in heart failure patients. Thu, 01 Jan 2026 00:00:00 GMT http://repository.usmf.md:80/xmlui/handle/20.500.12710/33499 2026-01-01T00:00:00Z