http://repository.usmf.md:80/xmlui/handle/20.500.12710/821 Sat, 04 Apr 2026 19:00:35 GMT 2026-04-04T19:00:35Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/27815 Anatomia patologică Strukov, A.; Serov, V. Fri, 01 Jan 1999 00:00:00 GMT http://repository.usmf.md:80/xmlui/handle/20.500.12710/27815 1999-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/2004 Morfopatologie generală Zota, Ieremia; Vataman, Vladimir Fri, 01 Jan 2010 00:00:00 GMT http://repository.usmf.md:80/xmlui/handle/20.500.12710/2004 2010-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/2003 General morphopathology: a compendium and atlas Zota, Ieremia; Burkes, Ernest Jefferson; Vataman, Vladimir Thu, 01 Jan 2004 00:00:00 GMT http://repository.usmf.md:80/xmlui/handle/20.500.12710/2003 2004-01-01T00:00:00Z http://repository.usmf.md:80/xmlui/handle/20.500.12710/2002 The influence of the tumoral cell proliferation rate in pituitary adenoma on expressing other factors with a prognostic role and therapeutic potential Melnic, Eugen Background: This article describes the growth rate of pituitary adenomas, their invasion and potential recurrence. Some of them grow rapidly while others remain in a dormant condition for a long time. The recurrence rate is also very hard to forecast. The pituitary adenomas that initially reduced their proliferation rate now acquire a rapid one, producing aggressive recurrences. Materials and methods: Eighty two cases of pituitary adenomas were studied. The classification of human pituitary adenomas has been profoundly assisted by immunohistochemistry. Ki-67 antibody was used to assess the proliferative index of pituitary adenomas. Results: Acidophil type adenomas or acidophil cells areas within mixed pituitary adenomas had the highest proliferation rate. Chromophobe pituitary adenomas were Ki67 negative in 90%, as well as the ones that presented the basophilic cells. The pituitary adenomas with a trabecular growth pattern had the lowest rate of proliferation, in about 50% of the cases being zero. The heterogeneity expression of growth factors and corresponding receptors is dependent on hormonal profile of pituitary adenomas. Conclusion: The pituitary adenomas proliferation rate depends on the type of secreted hormone as well as on the hormonal associations met in some cases of pituitary adenomas. Department of Morphopathology, Nicolae Testemitsanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova Thu, 01 Jan 2015 00:00:00 GMT http://repository.usmf.md:80/xmlui/handle/20.500.12710/2002 2015-01-01T00:00:00Z