Abstract:
Abstract
Introduction: Traditional methods of morphological studies cannot unambiguously assess the role of the radiation factor in brain damage. The aim of the work was to simulate changes in protein content in neurons of the
parietal cortex after fractionated gamma irradiation.
Material and method: The study was performed on 180 male rats at the age of 4 months, exposed to gamma
irradiation in total doses of 0.1; 0.2; and 1 Gy in equal portions for 5 days. The morphometric parameters and dynamics of the protein content in neurons were evaluated over the entire life span of the animals. When processing
the results, we used parametric criteria and mathematical modeling.
Result: In control and irradiated animals, wave-like changes in the protein content in neurons occur throughout life, with a gradual decrease in indicators towards the end of life. Regression analysis showed that irradiation
at the studied doses has a nonlinear stochastic effect on the protein content in neurons, does not have a dose-time
relationship, and does not cause significant organic changes in the brain.
Conclusion: no significant radiation-induced changes in the content and topochemistry of the products of
histochemical reactions were detected in the detection of protein in neurons of the parietal cortex.
Description:
Кафедра нормальной анатомии человека, Воронежский государственный медицинский университет им. Н.Н. Бурденко, Воронеж, Россия, Conferința Ştiinţifică Internaţională ”Probleme actuale ale morfologiei” dedicată celor 75 de ani de la fondarea Universităţii de Stat de Medicină și Farmacie Nicolae Testemiţanu, Chişinău, 30-31 octombrie 2020
