3D-модель гистогематического барьера кожи (ГГБК) для изучения локализации клещей рода Demodex у человека

Abstract

Abstract Background: Demodex (D.) mites were first identified by Henle F.G.J. in 1841, then Simon C. in 1842 described their structure. D. folliculorum, D. brevis and D. canis can inhabit humans skin. The role of mites in dermatological diseases is widely discussed. There are few studies on the effect of parasites on the skin microbiome and the course of dermatological pathologies, such as acne, rosacea, perioral dermatitis, seborrheic dermatitis. In our opinion, SHHB is one of the key components for the human skin protective function, and its penetration is a trigger for the start or exacerbation of pathologies. Material and methods: to visualize these processes and the role of SHHB in the pathogenesis of some facial dermatitis, for example dermatitis associated with Demodex mites, a 3D model of SHHB was created. Sequential stages of the model development: creating a drawing of a 3D model on paper, computer modeling and visualization of an object, printing on a 3D printer, coloring on a finished model. Results: the components of the SHHB: sebaceous-follicular complex, loose connective tissue and capillaries. Parasites can penetrate through various structures of the complex, localized in the sebaceous glands and enter the connective tissue or capillary bloodstream. Demodex mites can be one of the causes for exacerbation of dermatitis. Conclusion: Using the 3D-model made it possible to learning the Demodex mites influence on the state of SHHB.