Патоморфологические изменения яичников крыс при хронической алкогольной интоксикации

Abstract

Abstract Background: Ethanol is a biologically active substance with a broad pharmacological spectrum of action. It has a damaging effect on the female sex glands, disrupting the functional state of eggs, oogenesis processes, the structure and endocrine function of the gonads. In women of childbearing age who abuse alcohol, there is an early aging of the ovaries, due to the development of sclerocystic syndrome. Material and methods: The experiment was performed on 60 female white mongrel rats; group I-control, 20 immature females who received water, group II-20 immature females who received 0.5% alcohol for drinking, group III-20 sexually Mature females who received 0.5% alcohol for drinking. After the end of the experiment, the ovaries of the animals were fixed in 12% formalin and poured into paraffin blocks. Histological preparations were stained with hematoxylin-eosin. Results: The ovaries of immature females of the control group were covered with cubic epithelium. The cortical substance consisted of closely fusiform cells, in the stroma – primordial follicles. The brain matter contained a significant number of vessels of various calibers that entered and exited the ovarian gate. In the cortical substance of the ovaries of sexually Mature females exposed to ethanol intoxication, there were round hyperemic bodies of different sizes with a wide network of capillaries. The ovaries of experimental sexually Mature females are characterized by polycystic disease. Follicular cysts are filled with light fluid, and the basal membrane is thickened and deformed. The ovarian cortex contains a significant number of degenerating follicles. Conclusions: Ethanol is a cellular poison that causes various disorders in the process of germ cell ontogenesis, one of the reasons for the development of polycystic ovaries.