Морфометрия митоходрий печени при токсическом воздействии антиретровирусной терапии

Abstract

Abstract Background: Recently, mitochondrial dysfunction mechanisms play a central role in the development of side effects of antiretroviral drugs, which play a key role in the treatment of HIV infection. Material and methods: Morphometric parameters of hepatocyte mitochondria were studied in primary and repeated liver biopsy of HIV-infected patient with side effect lipodystrophy, while taking nucleoside reverse transcriptase inhibitors. Results: Under condition of antiretroviral toxic affect on liver mitochondria an increase in optical density matrix of the mitochondria, which indicates their condensation. According to the literature, these changes are accompanied by functional abnormalities of mitochondria and preceded by induction mediated mitochondrial mechanisms of programmed death of cells which occurs in the final stage of the mitochondrial apoptosis pathway. Intermembrane space expands, due to which the total amount of mitochondria remains the same. The most important functionally structure of mitochondria - the inner membrane - at this stage, maintained, despite the fact that the observed expansion of christie. Condensation and swelling of mitochondria may reflect functional cell voltage, but growing increasingly toxic effects. Conclusions: Thus, against toxic effects of antiretroviral drugs hepatocytes in liver tissue formed complex structural changes of mitochondria, more objective evidence of the development of degenerative diseases in these organelles in drug therapy for HIV infection.