Состояние ретикулярных волокон внеклеточного матрикса соединительной ткани тощей кишки мышей С57 black после 30-суточного космического полета

Abstract

Abstract Background: Connective tissue performs important functions in the organs, and provides the necessary conditions for the implementation of the functional activity of the cells and their derivatives. Of particular importance elements of connective tissue begin to acquire in space flight in connection with the role intraorganic skeleton. It is shown that in the stroma of weightlessness develop specific changes [2, 3, 4]. However thus far the only study of interstitial digestive system after space flight was performed on Mongolian gerbils. Many questions about the state of the connective tissue in space flight remains open. Material and methods: The methods of light-optical microscopy to study the content, topography and tinctorial characteristics of reticular fibers in the wall of the jejunum of mice C57 black after a 30-day orbital flight on Biological satellite «Bion-M» №1 and 7-day post-flight rehabilitation under ground conditions. Results: Conditions of space flight led to a reduction of reticular fibers in the wall of the jejunum, particularly in the muscular layer and the mucosa. During the 7-day rehabilitation after space flight there was a significant increase in fibrillogenesis reticular fibers in the wall of the jejunum. Ground modeling orbital flight in the layout of equipment “BIOS” did not cause changes in the connective tissue, which were discovered after space flight. Conclusions: The experiment shows the state of the connective tissue of the lean level of gravity. In weightlessness occurs adaptive remodeling of the extracellular matrix of connective tissue of the jejunum of mice C 57 black due to lower efficiency of fibrillogenesis, processes of restoration and revitalization lysis fibrous structures.