Эффективность радиопротекторов при комбинированных и сочетанных воздействиях на гетероморфные ткани

Abstract

Abstract Background: The problem of modification of effects of ionizing radiation in morphological manifestations of bodies with a different speed of updating is the actual direction of the last years. As development of pathological process after radiation and its outcome identification of the most effective mechanisms of mobilization of protective forces and restoration of functional reserves of an organism as a whole depend on the general resistance and a condition of systems of adaptation, is a perspective problem of modern radiobiology. Material and methods: As modifiers by us were considered: hypoxemic gas mix, normobarichesky oxygen and electromagnetic radiation which in certain conditions are interfaced to ionizing radiation, both in the conditions of emergence of emergency situations, and in a regular mode. Results: On the basis of studied literary yielded and results of own researches it is possible to note that extent of modification depended on sequence of use of modifiers and an ionizing radiation dose, and the radiprotektivny effect was in direct dependence on fabric accessory of body. Besides, the radio protective effect was found out at the previous combined and combined application of the changed gas environment with the raised and lowered content of oxygen and electromagnetic radiation that allows considering use of these modifiers perspective in the field of activity safety. Conclusions: 1. The early morphological symptoms of structural formations in the experiment. The specificity of violations, its dynamics and normalization conditions depend on the acting doses of ionizing radiation and the applied modifying factors, and tissue resistance; 2. Ascertain the effect of radio-AMY microwave range in conditions of combined exposure to γ-irradiation at a dose of 10 Gr in the first hours of the experiment for thyroid and in combination modified of the gaseous medium with γ-irradiation at a dose of 0.5 Gr to the mucosa of the jejunum in response to damage.