Состояние сателлитной глии нейронов спинномозговых узлов при раневом дефекте тканей в области их иннервации

Abstract

Abstract Background: The article shows the results of research about the morphological state of glial environment of dorsal root ganglion neurons in the process of healing the purulent wound in the area of their innervation. The experimental factors used in wound therapy are readjustment hydropressive sanitation and injection of platelet concentrate. Material and methods: The experiment was carried at 160 white male rats using classical histological techniques. Animals were distributed into 5 experimental groups: control, selective (both) and comprehensive application of the experimental therapeutic factors Results: Increase in the number of satellite cells is registered. Maximum values were observed on Day 21 of the experiment in the groups with spontaneous healing and selective application of platelet concentrate. Conclusions: The presence of wound defect in neuronal innervation leads DRG in parallel with a change in the structural and functional state of the nerve cells themselves, a significant restructuring of glial environment of neurons. Marked proliferation of satellite cells and change their attitude to the formation of multilayer structures in the capsule neuron. The degree of satellite cells amount correlates with the severity of the wound process – the number of satellite cells is higher, the longer the stage of inflammation and remodeling in wound defect.