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| dc.contributor.author | Golyak, Natalia | |
| dc.contributor.author | Malchenkova, Svetlana | |
| dc.date.accessioned | 2021-10-08T12:26:55Z | |
| dc.date.available | 2021-10-08T12:26:55Z | |
| dc.date.issued | 2021 | |
| dc.identifier.citation | GOLYAK, Natalia, MALCHENKOVA, Svetlana. In vitro dissolution profile of transdermal matrix ibuprofen patches using Paddle method. In: Revista Farmaceutică a Moldovei. 2021, vol. 45, nr. 1, pp. 52-54. ISSN 1812-5077. | en_US |
| dc.identifier.issn | 1812-5077 | |
| dc.identifier.uri | http://repository.usmf.md/handle/20.500.12710/18140 | |
| dc.description | Belarusian State Medical University, Minsk, Republic of Belarus | en_US |
| dc.description.abstract | Rezumat. Hidrogelul de poli(vinil pirolidonă) cu greutate moleculară mare (PVP) și poli(etilen glicol) 400 cu greutate moleculară mică (PEG 400) a fost utilizat ca matrice adezivă a sistemului de livrare transdermică a foribuprofenului. Au fost elaborate cinci plasturi, fiecare conţinând 0,2 ibuprofen. Testul de dizolvare a plasturilor transdermici a confirmat eliberarea ibuprofenului din matricea tuturor plasturilor și a determinat fluxul de ibuprofen. Fluxul mediu constant de ibuprofen a fost de 1,4 μg/cm2h pentru doi plasturi, 1,5 μg/cm2h pentru doi plasturi și 1,3 μg/cm2h pentru un plasture. | en_US |
| dc.description.abstract | Abstract. The hydrogel ofhigh molecular weight poly(vinyl pyrrolidone) (PVP) and low molecular weight poly(ethylene glycol) 400 (PEG 400) was used as adhesive matrix foribuprofen transdermal delivery system. Five patches were made, each containing 0,2 ibuprofen. The dissolution test for transdermal patches confirmed the release of ibuprofen from the matrix of all patches and determined the ibuprofen flux. The average constant ibuprofen flux was 1.4 μg / cm2 h for two patches, 1.5 μg/cm2 h for two patches, and 1.3 μg/cm2 h for one patch. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Asociația Farmaciștilor din Republica Moldova | en_US |
| dc.relation.ispartof | Revista Farmaceutică a Moldovei | en_US |
| dc.subject | ibuprofen | en_US |
| dc.subject | transdermal patch | en_US |
| dc.subject | PVP: PEG hydrogel | en_US |
| dc.subject.ddc | CZU: 615.212:615.477.66 | en_US |
| dc.title | In vitro dissolution profile of transdermal matrix ibuprofen patches using Paddle method | en_US |
| dc.title.alternative | Profilul de disoluţie in vitro al matricelor transdermale emplasturi cu ibuprofen utilizând metoda Padel | en_US |
| dc.type | Article | en_US |
