Efficacy of a fixed combination of Centaurii herba, Livestici radix and Rosmarini folium in urinary lithiasis: results of an open randomized cohort study

Abstract

Summary. Urolithiasis describes the formation of calculi in kidney and efferent urinary passages. If these calculi jam urinary passages, it is often associated with typical spastic pain attacks. Certain herbal drugs play a special role in urolithiasis prophylaxis and treatment. The herbal medical product Canephron® N, a combination of Centaurii herba, Levistici radix and Rosmarini folium, is established in the therapy of urolithiasis, the indication is proven by some clinical studies. In a randomised open monocentric add-on cohort study, the efficacy of Canephron® N was investigated for the treatment of urolithiasis. The herbal medical product was administered in 135 patients additionally to standard therapy, for comparison 102 patients were treated with standard therapy only. Canephron® N favours the spontaneous elimination of small calculi and significantly decreases leucocyturia, especially associated with urinary infection. Therefore it is justified to suggest the combination for prevention and/or in addition to standard therapy of urolithiasis.