Abstract:
Background: This article describes the growth rate of pituitary adenomas, their invasion and potential recurrence. Some of them grow rapidly while
others remain in a dormant condition for a long time. The recurrence rate is also very hard to forecast. The pituitary adenomas that initially reduced
their proliferation rate now acquire a rapid one, producing aggressive recurrences.
Materials and methods: Eighty two cases of pituitary adenomas were studied. The classification of human pituitary adenomas has been profoundly
assisted by immunohistochemistry. Ki-67 antibody was used to assess the proliferative index of pituitary adenomas.
Results: Acidophil type adenomas or acidophil cells areas within mixed pituitary adenomas had the highest proliferation rate. Chromophobe pituitary
adenomas were Ki67 negative in 90%, as well as the ones that presented the basophilic cells. The pituitary adenomas with a trabecular growth pattern
had the lowest rate of proliferation, in about 50% of the cases being zero. The heterogeneity expression of growth factors and corresponding receptors
is dependent on hormonal profile of pituitary adenomas.
Conclusion: The pituitary adenomas proliferation rate depends on the type of secreted hormone as well as on the hormonal associations met in some
cases of pituitary adenomas.
Description:
Department of Morphopathology, Nicolae Testemitsanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova