Evaluarea diagnostică a modificărilor biochimice din secretul prostatic în prostatita cronică

Abstract

Summary Chronic prostatitis is characterized by presentation of variable clinical features and frequent modification of paraclinical tests wich needs elaboration new methods for efficent diagnosis. The process of inflammation results in the initiation of synthesis of many biological active substances and its determination in expressed prostatic secretions gives important data for diagnosis of chronic prostatitis. To observe this modification, we studied 51 patients with chronic prostatic and 46 healthy men for biochemistry parameters: alkaline phosphatase (AP), total acid phosphatase (TAP), tartate dependent acid phosphatase (TDAP) and tartate independent acid phosphatase (TIAP), elastase (E), catepsine G (CG), N-acetyl-β-D-glucosaminidase (NAG), lysosyme (L), arylsulfatase A and В (ArAB), arylsulfatae C (ArC), (β glucuronidase (β-G), trypsine (T), α1 - antitrypsine (α1AT), total protein (PT) and phosphatic index (PI). These biochemical examination were performed by using spectrophotometry with biochemical analysis «ФП - 901». Phosphatic index was appreciated by ratio of TDAF to AP. The results of the biochemical examination performed showed the following statical variation (P<0,05): increased concentration of L by 60,5% and reduced activity of TDAP by 46,3%, ArAB - by 33,4%. AP - by 31,7%, TAP by 31,2%, PI by 30,0%. TIAP by 29,0% and E by 14,3%. Comparision between the healthy men and patients with chronic prostatitis with active inflamation showed significant changers like presence of 33,3±2,3 leucocytes in HPF (x280-400) and pH of prostatic secretion in affected men to be 7,6±0,1. Our conclusion from the study of biochemical modifications of the prostatic secretion in patients with chronic prostatitis is that AP, TAP, TDAP, TIAP, E, L, ArAB and PI denotes the active process of inflammation and there biochemical determination can help in great extent in the effective diagnosis of the chronic prostatitis.