Oxidative and antioxidative status in pregnant women with diabetes mellitus

Abstract

Objectives Pregnancy, especially due to increased oxygen demand is a condition that has increased sensitivity to oxidative stress. The aim of the study was to assess oxidant and antioxidant status in the third trimester of pregnancy in pregnant women with diabetes. Materials and Methods Cohort study : 112 pregnant with DM (basic lot-Lb) and 112 without DM (control lot-Lc), delivered in Institute of Mother and Child, Chișinău, Moldova. Lb was divided into 3 sublots: 35 (31,3%) with DM type 1 (Lb1), 20 (17,8%) with DM type 2 (Lb2) and 57 (50,9%) with GDM (Lb3). Results We found a significant increase in the blood serum of the pregnant with DM compared to those in the Lc of : malondialdehyde (MDA ) 8.96 ± 0.21 µM / L vs. 7.24 ± 0.15 µM / L ; advanced oxidation protein products (AOPPs) 88.99 ± 2.64 µM / L vs. 76.25 ± 1.51 µM / L and ischemia-modified albumin (IMA ) 0.54 ± 0.01mM / L vs. 0.45± 0.01mM / L . Lb2 and Lb3 vs. Lb1 : MDA 9.50 ± 0.76 µM / L and 9.15 ± 0.27 µM / L vs 8.33 ± 0.24 µM / L ; AOPPs 113.43 ± 9.62 µM / L and 85.10 ± 2.42 µM / L vs. 81.38 ± 3.93 µM / L . The antioxidant status showed a significant increase in pregnant with DM vs. Lcof : superoxide dismutase (SOD) 938.94 ± 17.11 u / c vs 763.24 ± 11.74 u / c ; total antioxidant capacity of various liquids (Cuprac ) 1.43 ± 0.15 mM / L vs. 0.77 ± 0.33 mM / L ; GST 37.94 ± 1.51nM / sL vs 28.97 ± 0.01 nM / sL. Conclusions Pregnancies with DM have been exposed to a more pronounced degree of oxidative stress compared to euglycemic ones.