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The frequency of pulmonary hypertension in chronic obstructive pulmonary disease of geriatric patients: a narrative literature review

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dc.contributor.author Luca, Ecaterina
dc.contributor.author Bodrug, Nicolae
dc.date.accessioned 2023-01-30T08:13:53Z
dc.date.available 2023-01-30T08:13:53Z
dc.date.issued 2022
dc.identifier.citation Luca, E., Bodrug, N. The frequency of pulmonary hypertension in chronic obstructive pulmonary disease of geriatric patients: a narrative literature review. Egypt J Intern Med 34, 47 (2022). https://doi.org/10.1186/s43162-022-00135-7 en_US
dc.identifier.issn 2090-9098
dc.identifier.uri https://ejim.springeropen.com/articles/10.1186/s43162-022-00135-7#citeas
dc.identifier.uri https://doi.org/10.1186/s43162-022-00135-7
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/23613
dc.description.abstract Background Pulmonary hypertension (PH) is a serious complication with complex pathogenesis in the natural history of chronic obstructive pulmonary disease COPD, with a progressively increasing frequency with a meanwhile decreasing in functional capacity. Purpose Assessment of the incidence, pathogenesis, peculiarities, and complications of PH in COPD in geriatric population worldwide. Methods We performed an analysis of randomized, retrospective, and prospective clinical, case-control and observational studies, published at the international level, according to the subject studied and target population. Four hundred ninety-seven full articles were identified after the search through engine Google Search and databases PubMed, Hinari, SpringerLink, and Scopus (Elsevier) according to the keywords and subsequent filters. Results Depending on various factors, like the population examined, the definition used for mPAP (mPAP> 20 mm Hg or ≥25 mm Hg), the severity of the lung disease, and the method of measuring PAP, a varied incidence of COPD patients with PH complication was discovered, namely 10–91%. PH prevalence increases with the COPD severity. The presence of PH is associated with acute exacerbations of COPD, reduced survival, and increasing expenses for healthcare programs. Mild to moderate levels of PH (mPAP 25–34 mm Hg) are relatively common in COPD and usually are associated with severe airflow obstruction or parenchymal destruction. Only a minority of patients (1–5%) have severe PH (mPAP ≥35 mm Hg). Conclusions Diagnosis of PH in COPD is difficult, especially in a mild form, and requires a clinical approach associated with a comprehensive set of investigations for confirming the etiology, evaluation of the functional and hemodynamical impairment severity, and important factors in the appropriate treatment election. en_US
dc.language.iso en en_US
dc.publisher SpringerOpen en_US
dc.relation.ispartofseries The Egyptian Journal of Internal Medicine en_US
dc.title The frequency of pulmonary hypertension in chronic obstructive pulmonary disease of geriatric patients: a narrative literature review en_US
dc.type Article en_US


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