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Comparative results between “epi-off” accelerated and “epi-off” standard corneal collagen crosslinking-UVA in progressive keratoconus -7 years of follow-up

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dc.contributor.author Nicula, Cristina Ariadna
dc.contributor.author Rednik, Anca Maria
dc.contributor.author Nicula, Ariadna Patricia
dc.contributor.author Bulboacă, Adriana Elena
dc.contributor.author Nicula, Dorin
dc.contributor.author Horvath, Karin Ursula
dc.date.accessioned 2023-04-07T10:12:31Z
dc.date.available 2023-04-07T10:12:31Z
dc.date.issued 2021
dc.identifier.citation NICULA, Cristina Ariadna, REDNIK, Anca Maria, NICULA, Ariadna Patricia, et al. Comparative results between “epi-off” accelerated and “epi-off” standard corneal collagen crosslinking-UVA in progressive keratoconus -7 years of follow-up. In: 19th Black Sea Ophthalmological Society Congress, September 24-26, 2021, Chisinau, Republic of Moldova: abstract book, p. 31. en_US
dc.identifier.uri https://aom.md/wp-content/uploads/2021/10/ABSTRACT-BOOK_web.pdf
dc.identifier.uri http://repository.usmf.md/handle/20.500.12710/24068
dc.description.abstract Purpose: The purpose of the present study was to assess the long-term efficiency and safety of the “epi-off” accelerated CXL (9 mW/cm2 for 10 minutes) in comparison to the standard “epi-off” CXL (3 mW/cm2 for 30 minutes) in terms of topographical and keratometric parameters, refractive data and visual outcomes at 7 years of follow-up, in progressive keratoconus. Material and method. A retrospective and comparative study was performed. A total of 183 eyes from 183 patients with documented progressive KCN were included in the study. The patients were divided in two groups: 93 eyes from 93 patients underwent “epi-off” standard cross-linking technique (3 mW/cm2 for 30 minutes) (S-CXL group) and 90 eyes from 90 patients underwent accelerated “epi-off” corneal CXL technique (9 mW/cm2 for 10 minutes) (A-CXL group). Results: Improvements in uncorrected distance visual acuity (UDVA) were statistically significant compared to baseline values in both groups at each time-point visit. (p=0.0421 at 1 year, p=0.0411 at 7 years for A-CXL and p=0.0375 at 1 year, p=0.0389 at 7 years for S-CXL). At 7 years there was a statistically significant increase in CDVA (p=0.039 in the A-CXL group and p=0.0343 in the S-CXL group at 7 years). Statistically significant reduction was noticed in Ksteep (p=0.0411 in A-CXL group and p=0.0224 in S-CXL group), Kflat (p=0.0198 in A-CXL group and p=0.008 in S-CXL group), K mean (p=0.0106 in A-CXL group and p=0.0193 in S-CXL group) and Kmax (p=0.0413 in A-CXL group and p=0.054 in S-CXL group) at 7 years, compared to baseline values, in both groups, but without any statistically difference between the two procedures, at all timepoint visits (p>0.05). Conclusions: The long-term outcomes of “epi-off” accelerated corneal collagen crosslinkingUVA (9 mW/cm2 for 10 minutes) are similar to standard “epi-off” corneal collagen crosslinking procedure in the treatment of progressive keratoconus. en_US
dc.language.iso en en_US
dc.publisher Black Sea Ophthalmological Society, Ophthalmological Association from Moldova, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova en_US
dc.relation.ispartof 19th Black Sea Ophthalmological Society Congress, September 24-26, 2021 Chisinau, Republic of Moldova en_US
dc.title Comparative results between “epi-off” accelerated and “epi-off” standard corneal collagen crosslinking-UVA in progressive keratoconus -7 years of follow-up en_US
dc.type Other en_US


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