Clinical and evolutive features of gouty arthritis

Abstract

Introduction. Gout is a disease that may be associated with different comorbidities, which causes difficulties in their management and appreciation of clinical manifestations. The objective of the study was to analyse the clinical and evolution peculiarities in patients with gout, from different age groups. Material and methods. A descriptive, selective study of 237 patients with gout (mean age of men 60±8.0 years and 63±9.0 years in women) was conducted. The diagnosis of gout was carried out according to the American College of Rheumatology and European League Against Rheumatism 2015 criteria. The patients were separated into two groups, depending on the age at the gout onset: <59 years (group I, 91 patients) and > 60 years (group II, 146 patients). The raw data were processed in SPSS version 26.0. Results. The mean duration of the disease was comparable in both groups: 11 [7.6; 18.6] years (from 1 month to 23.7 years (p = 0.7) in group I and 11.3 [8.3; 14] years (from 1.6 years to 21.8 years) in group II. The equivalent duration of arthritis allowed comparing the characteristics of evolution in the groups. The chronic form of gout arthritis was slightly more common in group II than in group I, with significant differences (24% and 34%, p<0.01). Conclusions. With the increase of age, the frequency of risk factors for gout increases: taking small doses of acetylsalicylic acid increases from 6 to 40%, diuretics from 18 to 44%, alcohol intake from 14 to 28%, hypertension from 44 to 78%, consumption of saturated foods with purine from 51 to 68%, overweight and obesity from 58 to 76% in the groups of patients with gout onset at the age less then 60 years and 60 years and more.