| dc.description.abstract |
Aim: The prognosis of chronic hepatitis C clinical course
Methods: The HLA AG of A, B, C locuses was investigated
in 11 patients with chronic hepatitis C (CHC) by the
method of complement/dependent cytotoxicity.
Results: Locuses B were found: B35 in 41 (6% of cases),
B5 – in 27 (2%), while locuses A: A2 – in 27, (2%) and
A10 – in 27, (2%). The comparison between basic markers
of main liver syndromes (cytolitic, cholestatic, hepatodepressive,
immune inflammation) and the phenotypes variants
in patients with CH C was carried out. The cytolisis
was more expressed in patients with HLA B35 (ALT –
154.03 4.59m/l, AST – 110.21 5.40m/l). The increasing
of CIC level (371.66 16,1UDO), decreasing of T-tot lymphocytes
to 616.5 35,0;43,83% 0,98 and T-sup
(194,50 4,24; 12,50% 0,54) with increasing of T-help/Tsup
ratio to 2,17 were found simultaneously. Meanwhile
in patients with HLA A2, B5 were found minimal clinical
manifestations: almost normal CIC levels, increasing of
IgG, decreasing of T-tot, T-help with increasing of T-sup
and lowering of T-help/T-sup indices to 0.29 and 0.36, correspondingly.
Moderate cytolitic syndrome with simultaneous
tension of humoral immune answer (>CIC, >IgG,
IgM) on the background of moderate T-tot and T-sup lymphocytes
decreasing, increasing of T-help account and Thelp/T-sup
index (3,76) were characteristic to the carries
of HLA A10.
Conclusion: These data may have the important significance for prognosis of clinical course, grade of liver disease
and estimation of risk groups of patients with HCV hepatitis for autoimmune disorders that are extremely important
in the case of antiviral therapy. |
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