Abstract:
Thesis structure: Introduction, 5 chapters, literature review, materials and methods, 3
original chapters, discussions, general conclusions, and recommendations, and bibliography of 221
titles, 2 appendices, 190 pages of basic text, 53 figures, 43 tables. The obtained results are
published in 52 scientific papers.
Keywords: pediatric craniofacial surgery, cranial suture, craniosynostosis, nonsyndromic
craniosynostosis, metopic craniosynostosis, unicoronal synostosis, cranial vault remodeling.
The aim of the study was the early surgical remodeling of the craniofacial parameters
responsible for the pathology of the craniofacial massif, with the application of the reconstructive
approach to reduce the potential action of the causal factors; improving the child's health and
aesthetic appearance. In this context, we formulated the objectives: analysis of the incidence of
craniofacial anomalies in children born in the Republic of Moldova, using standardized
anthropometric and cephalometric data (in a mixed population - urban and rural); evaluation of
craniofacial changes, syndromic and non-syndromic, in children by anthropometric and
cephalometric methods; the neurophysiological characteristic of the functional motor activity of
the sucking reflex of the child with craniofacial deformities preoperatively and postoperatively;
the therapeutic approach to craniofacial dysmorphism through treatment with special headphones
in different forms of clinical manifestation; synthesis of the criteria for surgical treatment and
postoperative recovery of craniofacial deformities according to their type and the age of the child,
with the elucidation of the criteria for the prophylaxis of secondary complications; estimating the
management strategy of children with craniofacial deformities, surgical and postoperative
reconstructive approaches, developing effective recovery criteria.
Novelty and scientific originality. The study represents the first attempt at complex,
comprehensive research at the national level of craniofacial dysmorphism in children from the
Republic of Moldova, followed by the improvement of the life quality in the postoperative period.
We pursued this aspect by analyzing the differentiation of neurophysiological and imaging
markers of the bone, muscle, and nervous system in children.
The important scientific problem. It deepens the knowledge of specialists of different
profiles regarding the onset and type of craniosynostosis in children of different ages. Highlighting
the neurophysiological variability of the bone-muscle-nerve complex function leads to the
highlighting of cerebral and facial asymmetry, early diagnosis, differentiation, and early
application.
Theoretical significance. The study of the facial asymmetry of the cranial box,
quantitative and qualitative, in relation to the deterioration of the sucking reflex, and
neurophysiological and imaging changes, can influence the curative and rehabilitation conduct
postoperatively.
The applied value of the works. The research results, conclusions, and practical
recommendations served to determine the diagnostic and treatment algorithm of craniofacial
deformities concerning the facial asymmetry degree of the craniofacial, neurophysiological,
imaging, and clinical parameters, especially with the impairment degree of the sucking reflex.
Implementation of the results. The obtained results in the scientific study implemented
in the Mother and Child Institute; Clinic Valentin Ignatenco; and in the IP USMF Nicolae
Testemitanu, 6 invention patents, 1 innovator's certificate, and 5 results implementation documents
were registered.
