dc.contributor.author | Nistor, Alesea | |
dc.date.accessioned | 2024-05-24T16:34:34Z | |
dc.date.available | 2024-05-24T16:34:34Z | |
dc.date.issued | 2024 | |
dc.identifier.uri | http://repository.usmf.md/handle/20.500.12710/27105 | |
dc.description.abstract | The actuality and significance of the topic. Some researchers consider that rheumatoid arthritis (RA) is not a single disease, but rather a collection of diseases. It could also be a disease with many different causes. However, RA is ultimately defined based on two main subtypes in adults: seropositive and seronegative. In seropositive RA, serological tests demonstrate high levels of antibodies called anti-cyclic citrullinated peptides (anti-CCP) and rheumatoid factor (RF). These are specific markers for RA and can appear long before overt symptoms of the disease. About 60% to 80% of people diagnosed with RA have anti-CCP and RF. By definition, people with seronegative RA do not have these antibodies and complexes in their serum, although this is controversial.[...] | en_US |
dc.language.iso | en | en_US |
dc.subject | rheumatoid arthritis | en_US |
dc.subject | seronegative | en_US |
dc.subject | early diagnosis | en_US |
dc.subject | seropositive | en_US |
dc.subject | rheumatoid factor | en_US |
dc.subject | anti-CCP | en_US |
dc.subject | citrullinated proteins | en_US |
dc.subject | joints | en_US |
dc.subject | HAQ | en_US |
dc.subject | acute phase markers | en_US |
dc.subject.ddc | C.Z.U: 616.72-002.77-07(043.2) | en_US |
dc.title | Early diagnosis and evolution of seronegative rheumatoid arthritis: 321.04 – Rheumatology: Summary of Doctor of Medical Sciences Thesis | en_US |
dc.type | Other | en_US |