Abstract:
Thesis structure. The work comprises 129 pages of text, and is organized as follows:
introduction, 4 chapters, general conclusions, practical recommendations, and a bibliography
index with 180 references. The illustrative material includes 33 figures, 2 tables, 1 statistical
formula, and 4 annexes. Additionally, the thesis topic has been the subject of 32 scientific papers,
including 4 solo-authored articles and 23 articles in peer-reviewed journals.
Keywords: borderline ovarian tumor, radical surgical treatment, conservative surgical
treatment, chemotherapy treatment, invasive implants, non-invasive implants, prognosis,
recurrence, survival.
Field of study: Medicine - oncology and radiotherapy.
The Purpose of the Study: is to optimize the methods of diagnosis and treatment
(surgical and chemotherapeutic) of patients with borderline ovarian tumors (BOT) according to
age and clinical-morphological factors to improve the quality of life.
Research objectives: to achieve the goal, the following research objectives were
stipulated: 1) clinical, paraclinical study and macroscopic intraoperative assessment of BOT;
2) studying morphological, immunohistochemical criteria in differentiating BOT from benign
ovarian tumors and ovarian cancer; 3) assessment of the indications for conservative and radical
surgical treatment according to the age of the patient and the stage of the tumor process;
4) assessment of chemotherapy treatment indications according to the stage of the tumor process;
5) developing the diagnosis and treatment algorithm of BOT.
The scientific novelty and originality of the work. The indications and
contraindications for radical or conservative surgical interventions (with preservation of
reproductive function) were determined according to the morphological subtype in patients with
BOT according to the morphological subtype, the indications and contraindications for the
administration of chemotherapeutic treatment with the aim of preventing recurrences and
metastases and to prolongation of survival in patients in advanced stages. Based on the risk factors,
the advantages and disadvantages of different surgical or combined treatment methods (surgical +
chemotherapy) in the reproductive, premenopause and menopause periods were specified, a fact
that contributed to the consolidation of surgical treatment methods and allowed the preservation
of the functions of reproduction, and for patients in advanced stages – increased survival.
The significant scientific problem addressed. In the paper consists in the optimization
of diagnostic and treatment methods (surgical and chemotherapeutic) in patients with BOT.
The theoretical significance of the work. Work consists in perfecting the management
methods of patients with BOT, the volume of surgical intervention depending on age, the
administration of chemotherapy treatment according to the stage and the morphological result, the
advantages and disadvantages, the indications and contraindications, as well as the survival rate
depending on the treatment applied.
The practical value of the work. The results of the study were the basis for the
development of practical recommendations in the conduct of gynecologists and oncologists to
optimize diagnosis, surgical and chemotherapeutic treatment, with the development of a diagnostic
and treatment algorithm, which makes it possible to personalize the conduct of patients with BOT.
Implementation of the Scientific Findings. The results of the study were implemented in
the didactic process of the Department of Oncology of IP USMF Nicolae Testemițanu for students,
residents and doctors within the Continuing Medical Education, as well as in the current curative
activity of the Oncological Institute.
