Abstract:
ABSTRACT
In this study autor purpose to evaluate the feasibility of using bovine fascia in the experimental substitution
of the fascial plan for the reconstruction of major anterior abdominal wall defects in the experimental
model.
Plastic reconstruction of the surgically induced abdominal wall defect using decellularized bovine fascia
grafts was performed on 5-week-old Landrace pigs (3 animals) in which the abdominal wall defect of 10x5.0
cm was surgically induced with the involvement of all layers, including the peritoneum. The animals were
subsequently euthanized 90 days after the intervention. For decellularization, sterile 0.5% SDS solution
(HiMedia) was used in volume required to obtain acellular tissues. The solution was changed every 24 hours
for 72 hours.
The preventive results of the histopathological examination allowed the author to conclude that the use
of decellularized bovine fascia grafts in the experimental model is characterized by the dominance of active
regenerative processes with tissue remodeling and host cell invasion, the xenogeneic implant tissues being
subjected to gradual degradation and substituted with the neoformed host connective tissue, the rationale
of the usefulness of this biological material requiring additional comparative and clinical immunological
studies.
The results of this experimental study allow us to conclude the following that the usage of bovine fascia
acellular grafts as an alternative xenogeneic biological implant in reconstructive surgery of abdominal wall
defects, this option requiring additional comparative and clinical immunological studies.
Description:
Public Institution State University of Medicine and Pharmacy “Nicolae Testemiţanu”,
PMSI Mother and Child Institute, Chisinau, Republic of Moldova
